Rabbit anti-Human CDS2 Polyclonal Antibody | anti-CDS2 antibody

CDS2, ID (CDS2, Phosphatidate cytidylyltransferase 2, CDP-DAG synthase 2, CDP-DG synthase 2, CDP-diacylglycerol synthase 2, CDP-diglyceride pyrophosphorylase 2, CDP-diglyceride synthase 2, CTP:phosphatidate cytidylyltransferase 2) (Azide free) (HRP)

Cat. Num. AAA6284802

• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: CDS2; Polyclonal Antibody; ID (CDS2; Phosphatidate cytidylyltransferase 2; CDP-DAG synthase 2; CDP-DG synthase 2; CDP-diacylglycerol synthase 2; CDP-diglyceride pyrophosphorylase 2; CDP-diglyceride synthase 2; CTP:phosphatidate cytidylyltransferase 2) (Azide free) (HRP); CTP:phosphatidate cytidylyltransferase 2; anti-CDS2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-CDS2 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: CDS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 137-165 amino acids from the Central region of human CDS2.
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(CDS2 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the CDS2 antibody detected the CDS2 protein (arrow).)

Related Product Information for anti-CDS2 antibody

Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13.

Product Categories/Family for anti-CDS2 antibody

Antibodies; CD Markers

References

Bailey, S.D., et al. Diabetes Care (2010). In press: Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009). Olsen, J.V., et al. Cell 127(3):635-648(2006). Olsen, J.V., et al. Cell 127(3):635-648(2006).

NCBI and Uniprot Product Information

• NCBI GI #: 20143480
• NCBI GeneID: 8760
• NCBI Accession #: NP_003809.1
• NCBI GenBank Nucleotide #: NM_003818.3
• UniProt Accession #: O95674; Q5TDY2; Q5TDY3; Q5TDY4; Q5TDY5; Q9BYK5; Q9NTT2; B2RDC6; D3DW04
• Molecular Weight: 51,418 Da
• NCBI Official Full Name: phosphatidate cytidylyltransferase 2
• NCBI Official Synonym Full Names: CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
• NCBI Official Symbol: CDS2
• NCBI Protein Information: phosphatidate cytidylyltransferase 2; CDS 2; CDP-DG synthase 2; CDP-DAG synthase 2; CDP-DG synthetase 2; CDP-diglyceride synthase 2; CDP-diglyceride synthetase 2; CDP-diacylglycerol synthase 2; CDP-diglyceride diphosphorylase 2; CDP-diglyceride pyrophosph
• UniProt Protein Name: Phosphatidate cytidylyltransferase 2
• Protein Family: Phosphatidate cytidylyltransferase
• UniProt Gene Name: CDS2
• UniProt Synonym Gene Names: CDS 2
• UniProt Entry Name: CDS2_HUMAN

Uniprot Description

CDS2: Provides CDP-diacylglycerol an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. Belongs to the CDS family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid Metabolism - glycerophospholipid; Mitochondrial; Transferase; Membrane protein, multi-pass; Endoplasmic reticulum; EC 2.7.7.41; Membrane protein, integral

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: membrane; endoplasmic reticulum; mitochondrial inner membrane; integral to membrane

Molecular Function: phosphatidate cytidylyltransferase activity

Biological Process: phosphatidylglycerol biosynthetic process; phospholipid metabolic process; glycerophospholipid biosynthetic process; CDP-diacylglycerol biosynthetic process