Rabbit anti-Human, Mouse Cdk14 Polyclonal Antibody | anti-Cdk14 antibody

Cdk14, NT (Cdk14, Kiaa0834, Pftk1, Cyclin-dependent kinase 14, Cell division protein kinase 14, Serine/threonine-protein kinase PFTAIRE-1) (Biotin)

Cat. Num. AAA6284283

• Gene Names: Cdk14; Pftk1; mKIAA0834
• Reactivity: Human, Mouse
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: Cdk14; Polyclonal Antibody; NT (Cdk14; Kiaa0834; Pftk1; Cyclin-dependent kinase 14; Cell division protein kinase 14; Serine/threonine-protein kinase PFTAIRE-1) (Biotin); Serine/threonine-protein kinase PFTAIRE-1; anti-Cdk14 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-Cdk14 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: Mouse Cdk14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 44-72 amino acids from the N-terminal region of mouse Cdk14.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Mouse Cdk14 Antibody (N-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the Mouse Cdk14 antibody detected the Mouse Cdk14 protein (arrow).)

Related Product Information for anti-Cdk14 antibody

Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport (By similarity).

Product Categories/Family for anti-Cdk14 antibody

Antibodies; Protein Kinases

References

Quina, L.A., et al. J. Neurosci. 29(45):14309-14322(2009). Jiang, M., et al. FEBS Lett. 583(13):2171-2178(2009). Jones, B.C., et al. Am. J. Physiol. Regul. Integr. Comp. Physiol. 293 (1), R116-R124 (2007): Visel, A., et al. Nucleic Acids Res. 32 (DATABASE ISSUE), D552-D556 (2004): Okazaki, N., et al. DNA Res. 10(4):167-180(2003).

NCBI and Uniprot Product Information

• NCBI GI #: 161086911
• NCBI GeneID: 18647
• NCBI Accession #: NP_035204.2
• NCBI GenBank Nucleotide #: NM_011074.3
• UniProt Accession #: O35495; O35848; Q3TNN9; Q3V319; Q6ZQ37
• Molecular Weight: 41,378 Da
• NCBI Official Full Name: cyclin-dependent kinase 14 isoform 1
• NCBI Official Synonym Full Names: cyclin-dependent kinase 14
• NCBI Official Symbol: Cdk14
• NCBI Official Synonym Symbols: Pftk1; mKIAA0834
• NCBI Protein Information: cyclin-dependent kinase 14
• UniProt Protein Name: Cyclin-dependent kinase 14
• Protein Family: Cyclin-dependent kinase
• UniProt Gene Name: Cdk14
• UniProt Synonym Gene Names: Kiaa0834; Pftk1

Uniprot Description

Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport ().