Rabbit CDCP1 Polyclonal Antibody | anti-CDCP1 antibody

Rabbit Polyclonal to Human CDCP1

Cat. Num. AAA244483

• Gene Names: CDCP1; CD318; TRASK; SIMA135
• Reactivity: Gibbon, Gorilla, Human, Orangutan; Predicted Reactivity: Chimpanzee, Monkey (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: CDCP1; Polyclonal Antibody; Rabbit Polyclonal to Human CDCP1; Anti-CDCP1 Antibody (N-Terminus) IHC-plus; CD318 antigen; Membrane glycoprotein gp140; SIMA135; TRASK; CD318; Human CDCP1; anti-CDCP1 antibody

• Host: Rabbit
• Reactivity: Gibbon, Gorilla, Human, Orangutan; Predicted Reactivity: Chimpanzee, Monkey (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human CDCP1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 836

• Applicable Applications for anti-CDCP1 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (5 - 10 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 15 amino acid peptide from N-Terminus of human CDCP1. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Marmoset (100%); Chimpanzee, Monkey (93%).
• Immunogen Type: Synthetic peptide
• Immunogen: CDCP1 antibody was raised against synthetic 15 amino acid peptide from N-Terminus of human CDCP1. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Marmoset (100%); Chimpanzee, Monkey (93%).
• Antigen Modification: N-Terminus
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Human, Prostate: Formalin-Fixed Paraffin-Embedded (FFPE))

Immunohistochemistry (IHC)

(Human, Liver: Formalin-Fixed Paraffin-Embedded (FFPE))

Related Product Information for anti-CDCP1 antibody

CDCP1 (Cub Domain Containing Protein) was isolated by representational difference analysis using extracts from colon carcinoma and normal colon. It is a putative transmembrane protein with three CUB domains and is thought to be involved in cell adhesion or interaction with the extracellular matrix. CDCP1 undergoes phosphorylation on tyrosine and may undergo shedding as the protein has been detected in the lumen of both normal and cancerous colon crypts by IHC.

NCBI and Uniprot Product Information

• NCBI GI #: 30410805
• NCBI GeneID: 64866
• NCBI Accession #: NP_073753.3
• NCBI GenBank Nucleotide #: NM_022842.4
• UniProt Accession #: Q9H5V8; Q49UB4; Q6NT71; Q6U9Y2; Q8WU91; Q96QU7; Q9H676; Q9H8C2
• Molecular Weight: 37,818 Da
• NCBI Official Full Name: CUB domain-containing protein 1 isoform 1
• NCBI Official Synonym Full Names: CUB domain containing protein 1
• NCBI Official Symbol: CDCP1
• NCBI Official Synonym Symbols: CD318; TRASK; SIMA135
• NCBI Protein Information: CUB domain-containing protein 1; membrane glycoprotein gp140; transmembrane and associated with src kinases; subtractive immunization M plus HEp3-associated 135 kDa protein
• UniProt Protein Name: CUB domain-containing protein 1
• Protein Family: CUB domain-containing protein
• UniProt Gene Name: CDCP1
• UniProt Synonym Gene Names: TRASK; SIMA135
• UniProt Entry Name: CDCP1_HUMAN

NCBI Description

This gene encodes a transmembrane protein which contains three extracellular CUB domains and acts as a substrate for Src family kinases. The protein plays a role in the tyrosine phosphorylation-dependent regulation of cellular events that are involved in tumor invasion and metastasis. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

Uniprot Description

CDCP1: a transmembrane protein containing three extracellular CUB domains involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation depending upon its phosphorylation status. Interacts with N- and P-cadherin, syndecans 1 and 4, the serine protease ST14, SRC and PKCG. Highly expressed in mitotic cells with low expression during interphase. Detected at highest levels in skeletal muscle and colon with lower levels in kidney, small intestine, placenta and lung. Up-regulated in a number of human tumor cell lines, as well as in colorectal cancer, breast carcinoma and lung cancer. Its expression level is correlated with the metastatic ability of carcinoma cells. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis. Also expressed in cells with phenotypes reminiscent of mesenchymal stem cells and neural stem cells. Three alternatively spliced human isoforms have been reported. Isoform 1 is a single-pass membrane protein that may also be shed, giving rise to a soluble peptide. Isoform 3 is secreted.

Protein type: Membrane protein, integral; Cell surface

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: integral to membrane; extracellular region; plasma membrane