Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 46445(CDC45 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200))
Rabbit anti-Human CDC45 Polyclonal Antibody | anti-CDC45 antibody
CDC45 Antibody
Gene Names
CDC45; CDC45L; MGORS7; CDC45L2; PORC-PI-1
Reactivity
Human
Applications
Immunohistochemistry
Purity
Antigen affinity purification
Synonyms
CDC45; Polyclonal Antibody; CDC45 Antibody; CDC45L; CDC45L2; PORC-PI-1; anti-CDC45 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
The antibody detects endogenous levels of total CDC45 protein.
Purity/Purification
Antigen affinity purification
Form/Format
In pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Concentration
0.4mg/ml (varies by lot)
Sequence Length
1905
Applicable Applications for anti-CDC45 antibody
Immunohistochemistry (IHC)
Application Notes
IHC: 1: 30-150
Immunogen
Synthetic protein corresponding to residues near the C terminal of human CDC45
Immunogen Type
Peptide
Preparation and Storage
Store at -20 degree C.
Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 46445(CDC45 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200))
Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 46445(CDC45 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200))
Related Product Information for anti-CDC45 antibody
The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants.
Product Categories/Family for anti-CDC45 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
68,768 Da
NCBI Official Full Name
Homo sapiens CDC45 cell division cycle 45-like (S. cerevisiae), mRNA
NCBI Official Synonym Full Names
cell division cycle 45
NCBI Official Symbol
CDC45
NCBI Official Synonym Symbols
CDC45L; MGORS7; CDC45L2; PORC-PI-1
NCBI Protein Information
cell division control protein 45 homolog
UniProt Protein Name
Cell division control protein 45 homolog
Protein Family
UniProt Gene Name
CDC45
UniProt Synonym Gene Names
CDC45L; CDC45L2
NCBI Description
The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Description
Required for initiation of chromosomal DNA replication.
Research Articles on CDC45
Similar Products
Product Notes
The CDC45 cdc45 (Catalog #AAA9429592) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CDC45 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CDC45 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). IHC: 1: 30-150. Researchers should empirically determine the suitability of the CDC45 cdc45 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CDC45, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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