Western Blot (WB)
(Anti-CD89 antibody, MBS175531, Western blottingLane 1: A549 Cell LysateLane 2: U87 Cell LysateLane 3: RAJI Cell LysateLane 4: JURKAT Cell Lysate )
Rabbit anti-Human CD89 Polyclonal Antibody | anti-FCAR antibody
Anti-CD89 antibody
Western Blot (WB)
(Anti-CD89 antibody, MBS175531, Western blottingLane 1: A549 Cell LysateLane 2: U87 Cell LysateLane 3: RAJI Cell LysateLane 4: JURKAT Cell Lysate )
Western Blot (WB)
(Anti-CD89 antibody, MBS175531, Western blottingLane 1: A549 Cell LysateLane 2: U87 Cell LysateLane 3: RAJI Cell LysateLane 4: JURKAT Cell Lysate )
Background: FCAR, Receptor for Fc fragment of IGA, is also known as CD89. Human Fc-alpha receptor(FCAR) is present on a number of cell types, including neutrophils, monocytes, macrophages, and eosinophils. FCAR interacts with aggregated IgAs, such as IgA coated on the surface of an invading microorganism, and mediates several immunologic defense processes such as phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. FCAR is a glycoprotein of 50 to 100 kD, with diversity on different cell types. FCAR is mapped to 19q13.4. Human COS cells transfected with FCAR cDNA bind to IgA, but not IgG.
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
FCAR: Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production. 11 isoforms of the human protein are produced by alternative splicing.
Protein type: Immunoglobulin superfamily; Membrane protein, integral
Chromosomal Location of Human Ortholog: 19q13.42
Cellular Component: integral to plasma membrane; plasma membrane; extracellular region
Molecular Function: IgA binding
Biological Process: immune response
Research Articles on FCAR
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Product Notes
The FCAR fcar (Catalog #AAA175531) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-CD89 antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CD89 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the FCAR fcar for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD89, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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