Rabbit anti-Mouse, Rat CD55 Polyclonal Antibody | anti-CD55 antibody

CD55 Polyclonal Antibody

Cat. Num. AAA3015189

• Gene Names: Cd55b; Daf; Daf2; Daf-TM; TM-DAF; AI323748
• Reactivity: Mouse, Rat
• Applications: Western Blot
• Purity: affinity purified by Protein A
• Synonyms: CD55; Polyclonal Antibody; CD55 Polyclonal Antibody; CD 55; CD55 antigen; CD55 Cromer blood group system; CD55 molecule; decay accelerating factor for complement (Cromer blood group); Cd55a; Complement decay accelerating factor; Complement decay-accelerating factor; GPI-anchored; CR; CROM; Cromer Blood Group antigen; Cromer blood group system; DAF; Daf-GPI; DAF_HUMAN; Daf1; Dcay accelerating factor for complement (CD55; Cromer blood group system); Decay accelarating factor 1; isoform CRA_a; Decay accelerating factor (GPI-form); Decay Accelerating Factor for Complement; Decay accelerating factor GPI-form; Decay accelerating factor soluble-form; GPI-DAF; TC; anti-CD55 antibody

• Host: Rabbit
• Reactivity: Mouse, Rat
• Clonality: Polyclonal
• Specificity: CD55 Polyclonal Antibody detects endogenous levels of CD55 protein.
• Purity/Purification: affinity purified by Protein A
• Form/Format: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

• Applicable Applications for anti-CD55 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-2000
• Immunogen: KLH conjugated synthetic peptide derived from mouse CD55
• Preparation and Storage: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Testing Data

Testing Data

Related Product Information for anti-CD55 antibody

This gene encodes a protein involved in the regulation of the complement cascade. The encoded glycoprotein is also known as the decay-accelerating factor (DAF); binding of DAF to complement proteins accelerates their decay, disrupting the cascade and preventing damage to host cells. Antigens present on the DAF glycoprotein constitute the Cromer blood group system (CROM). Two alternatively spliced transcripts encoding different proteins have been identified. The predominant transcript encodes a membrane-bound protein expressed on cells exposed to plasma component proteins but an alternatively spliced transcript produces a soluble protein present at much lower levels. Additional, alternatively spliced transcript variants have been described, but their biological validity has not been determined.

NCBI and Uniprot Product Information

• NCBI GI #: 958157202
• NCBI GeneID: 13137
• NCBI Accession #: NP_001304290.1
• NCBI GenBank Nucleotide #: NM_001317361.1
• UniProt Accession #: Q61476; E9QLT3
• Molecular Weight: 44,511 Da
• NCBI Official Full Name: complement decay-accelerating factor transmembrane isoform isoform 2
• NCBI Official Synonym Full Names: CD55 molecule, decay accelerating factor for complement B
• NCBI Official Symbol: Cd55b
• NCBI Official Synonym Symbols: Daf; Daf2; Daf-TM; TM-DAF; AI323748
• NCBI Protein Information: complement decay-accelerating factor transmembrane isoform
• UniProt Protein Name: Complement decay-accelerating factor transmembrane isoform
• Protein Family: Complement decay-accelerating factor
• UniProt Gene Name: Cd55b
• UniProt Synonym Gene Names: Daf2; DAF-TM

NCBI Description

This gene encodes an inhibitor of both the classical and the alternative pathways of complement activation. This gene is located adjacent to a closely related gene on chromosome 1 and preferentially expressed in the spleen and testis. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2015]

Uniprot Description

This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage.