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Rabbit CD44V7 Polyclonal Antibody | anti-Cd44 antibody

CD44V7 (HCAM, Homing Cell Adhesion Molecule, Pgp-1, Phagocytic Glycoprotein-1, Hermes Antigen, Lymphocyte Homing Receptor, ECM-III, HUTCH-1)

Gene Names
Cd44; Ly-24; Pgp-1; HERMES; AU023126; AW121933; AW146109
Reactivity
Bovine, Canine, Human, Mouse, Porcine, Rabbit, Rat
Applications
ELISA, Western Blot, Immunoprecipitation, Immunohistochemistry, Flow Cytometry, Functional Assay, Immunofluorescence, immunoassay, Radioimmunoassay
Purity
Purified
Purified
Synonyms
CD44V7; Polyclonal Antibody; CD44V7 (HCAM; Homing Cell Adhesion Molecule; Pgp-1; Phagocytic Glycoprotein-1; Hermes Antigen; Lymphocyte Homing Receptor; ECM-III; HUTCH-1); Anti -CD44V7 (HCAM; anti-Cd44 antibody
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For Research Use Only!
Host
Rabbit
Reactivity
Bovine, Canine, Human, Mouse, Porcine, Rabbit, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human CD44v7 (~200-250kD).
Purity/Purification
Purified
Purified
Form/Format
Supplied as a liquid in PBS, 0.01% sodium azide.
Applicable Applications for anti-Cd44 antibody
ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS), Immunofluorescence (IF), Radioimmunoassay (RIA)
Application Notes
Suitable for use in ELISA, Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot and RIA.
Dilution: ELISA: 1:1000-1:2000
Flow Cytometry: 1:500-1:1000
Immunofluorescence: 1:100-1:200
Immunohistochemisty (Paraffin): 1:150-1:250
Immunoprecipitation: 1:100-1:200
Western Blot: 1:5000-1:10,000
RIA: 1:5000
Optimal dilution determined by the researcher.
Immunogen
Synthetic peptide corresponding to human CD44v7.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-Cd44 antibody
Recent studies indicate that the expression of CD44 on the cell surface changes profoundly during tumor metastasis, particularly during the progression of various carcinomas. Sequencing analysis reveals that CD44 exists in different forms (at least 15 isoforms have been identified) that are variants of the common or standard hemopoietic form CD44s. Specifically, the human CD44 gene contains 19 exons, out of which 10 exons can potentially be alternatively spliced. In particular, CD44s contains exons 1-15 and exons 15-19. The other exons (e.g. 6-14) are also spliced in a variety of different cells. For example, epithelial cells contain exons 12-14 inserted into the CD44s transcripts. This isoform has been designated as CD44E. Other CD44 variants CD44v) have the same sequences at the two ends of the molecule, but differ in a middle region (with different numbers of additional exons) located on the external side of the cell membrane. It has been suggested that expression of CD44 variants with the additional exon 11 (so-called v7) is responsible for tumor progression and metastasis. In fact, CD44v7 expression has been used as an indicator of metastasis.
Product Categories/Family for anti-Cd44 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
Molecular Weight
85,617 Da
NCBI Official Full Name
CD44 antigen
NCBI Official Synonym Full Names
CD44 antigen
NCBI Official Symbol
Cd44
NCBI Official Synonym Symbols
Ly-24; Pgp-1; HERMES; AU023126; AW121933; AW146109
NCBI Protein Information
CD44 antigen; PGP-I; HUTCH-I; ECMR-III; hermes antigen; hyaluronate receptor; lymphocyte antigen 24; phagocytic glycoprotein 1; phagocytic glycoprotein I; extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor
UniProt Protein Name
CD44 antigen
Protein Family
UniProt Gene Name
Cd44
UniProt Synonym Gene Names
Ly-24; ECMR-III; Ly-24; PGP-1; PGP-I
UniProt Entry Name
CD44_MOUSE

Uniprot Description

CD44: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Interacts with PKN2. Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells. 19 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral; Receptor, misc.

Cellular Component: Golgi apparatus; focal adhesion; protein complex; cell surface; membrane; basolateral plasma membrane; cytoplasm; apical plasma membrane; integral to membrane; plasma membrane; nucleus; external side of plasma membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; cytokine binding; hyaluronic acid binding; phosphoprotein binding; protein kinase binding; hyalurononglucosaminidase activity; epidermal growth factor receptor binding

Biological Process: cell migration; Wnt receptor signaling pathway; positive regulation of heterotypic cell-cell adhesion; positive regulation of neutrophil apoptosis; negative regulation of caspase activity; positive regulation of peptidyl-serine phosphorylation; hyaluronan catabolic process; negative regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of mature B cell apoptosis; ureteric bud branching; regulation of cell growth; cell adhesion; healing during inflammatory response; neurite development; positive regulation of adaptive immune response; negative regulation of apoptosis

Research Articles on Cd44

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Product Notes

The Cd44 cd44 (Catalog #AAA614720) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CD44V7 (HCAM, Homing Cell Adhesion Molecule, Pgp-1, Phagocytic Glycoprotein-1, Hermes Antigen, Lymphocyte Homing Receptor, ECM-III, HUTCH-1) reacts with Bovine, Canine, Human, Mouse, Porcine, Rabbit, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CD44V7 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS), Immunofluorescence (IF), Radioimmunoassay (RIA). Suitable for use in ELISA, Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot and RIA. Dilution: ELISA: 1:1000-1:2000 Flow Cytometry: 1:500-1:1000 Immunofluorescence: 1:100-1:200 Immunohistochemisty (Paraffin): 1:150-1:250 Immunoprecipitation: 1:100-1:200 Western Blot: 1:5000-1:10,000 RIA: 1:5000 Optimal dilution determined by the researcher. Researchers should empirically determine the suitability of the Cd44 cd44 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD44V7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.
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