Rabbit CD239/BCAM Polyclonal Antibody | anti-BCAM antibody

Anti-CD239/BCAM Antibody

Cat. Num. AAA1753068

• Gene Names: BCAM; AU; LU; CD239; MSK19
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Flow Cytometry, Functional Assay
• Purity: Immunogen affinity purified.
• Synonyms: CD239/BCAM; Polyclonal Antibody; Anti-CD239/BCAM Antibody; Basal cell adhesion molecule; Auberger B antigen; B-CAM cell surface glycoprotein; F8/G253 antigen; Lutheran antigen; Lutheran blood group glycoprotein; CD239; BCAM; LU; MSK19; anti-BCAM antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: No cross reactivity with other proteins.
• Purity/Purification: Immunogen affinity purified.
• Form/Format: Lyophilized; Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Sequence Length: 628

• Applicable Applications for anti-BCAM antibody: Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FC/FACS)
• Application Notes: WB: 0.25-0.5ug/ml (Human, Mouse, Rat); IHC-P (Embedded Section): 0.5-1ug/ml (Human); ICC: 2ug/ml (Human); IF: 2ug/ml (Human); FC/FACS: 1-3ug/1x106 cells (Human); Tested Species: In-house tested species with positive results.
• Immunogen: A synthetic peptide corresponding to a sequence of human CD239/BCAM (LLSLTSTLYLRLRKDDRDASFHCAAHYSLPEGRH).
• Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
• Preparation and Storage: Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen store at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Related Product Information for anti-BCAM antibody

Description: Rabbit IgG polyclonal antibody for CD239/BCAM detection. Tested with WB, IHC-P, ICC/IF, FCM in Human; Mouse; Rat.

Background: Basal cell adhesion molecule, also known as Lutheran antigen, is a plasma membraneglycoprotein that in humans is encoded by the BCAM gene. It is mapped to 19q13.32. This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene.

References

1. Campbell, I. G., Foulkes, W. D., Senger, G., Trowsdale, J., Garin-Chesa, P., Rettig, W. J. Molecular cloning of the B-CAM cell surface glycoprotein of epithelial cancers: a novel member of the immunoglobulin superfamily. Cancer Res. 54: 5761-5765, 1994.
2. Cook, P. J. L. The Lutheran-secretor recombination fraction in man: a possible sex difference. Ann. Hum. Genet. 28: 393-401, 1965.
3. Daniels, G. L., Le Pennec, P. Y., Rouger, P., Salmon, C., Tippett, P. The red cell antigens Au(a) and Au(b) belong to the Lutheran system. Vox Sang. 60: 191-192, 1991.

NCBI and Uniprot Product Information

• NCBI GI #: 92058724
• NCBI GeneID: 4059
• UniProt Accession #: P50895
• NCBI Official Full Name: Basal cell adhesion molecule
• NCBI Official Synonym Full Names: basal cell adhesion molecule (Lutheran blood group)
• NCBI Official Symbol: BCAM
• NCBI Official Synonym Symbols: AU; LU; CD239; MSK19
• NCBI Protein Information: basal cell adhesion molecule
• UniProt Protein Name: Basal cell adhesion molecule
• Protein Family: Basal cell adhesion molecule
• UniProt Gene Name: BCAM
• UniProt Synonym Gene Names: LU; MSK19

NCBI Description

This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Uniprot Description

Laminin alpha-5 receptor. May mediate intracellular signaling.