Rabbit CD108 Polyclonal Antibody | anti-CD108 antibody

CD108 Polyclonal Antibody

Cat. Num. AAA9419794

• Gene Names: SEMA7A; JMH; CD108; SEMAL; CDw108; SEMAK1; H-Sema-L; H-SEMA-K1
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: Affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
• Synonyms: CD108; Polyclonal Antibody; CD108 Polyclonal Antibody; Semaphorin-7A (CDw108) (JMH blood group antigen) (John-Milton-Hargen human blood group Ag) (Semaphorin-K1) (Sema K1) (Semaphorin-L) (Sema L) (CD antigen CD108); anti-CD108 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous CD108
• Purity/Purification: Affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
• Form/Format: PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
• Concentration: 1 mg/ml (varies by lot)

• Applicable Applications for anti-CD108 antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-300
• Immunogen: Synthetic peptide from human protein at AA range: 101-150
• Immunogen Type: Protein
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:200)

Product Categories/Family for anti-CD108 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 225637520
• NCBI GeneID: 8482
• NCBI Accession #: NP_001139501.1
• NCBI GenBank Nucleotide #: NM_001146029.2
• UniProt Accession #: O75326; Q1XE81; Q1XE82; Q1XE83; Q1XE84; Q3MIY5; B4DDP7; F5H1S0
• Molecular Weight: 73,364 Da
• NCBI Official Full Name: semaphorin-7A isoform 2
• NCBI Official Synonym Full Names: semaphorin 7A (John Milton Hagen blood group)
• NCBI Official Symbol: SEMA7A
• NCBI Official Synonym Symbols: JMH; CD108; SEMAL; CDw108; SEMAK1; H-Sema-L; H-SEMA-K1
• NCBI Protein Information: semaphorin-7A
• UniProt Protein Name: Semaphorin-7A
• UniProt Gene Name: SEMA7A
• UniProt Synonym Gene Names: CD108; SEMAL; Sema K1; Sema L

NCBI Description

This gene encodes a member of the semaphorin family of proteins. The encoded preproprotein is proteolytically processed to generate the mature glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein. The encoded protein is found on activated lymphocytes and erythrocytes and may be involved in immunomodulatory and neuronal processes. The encoded protein carries the John Milton Hagen (JMH) blood group antigens. Mutations in this gene may be associated with reduced bone mineral density (BMD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

Uniprot Description

SEMA7A: Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes. Belongs to the semaphorin family.

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 15q24.1

Cellular Component: external side of plasma membrane; extracellular space; membrane; plasma membrane

Molecular Function: integrin binding; protein binding

Biological Process: immune response; integrin-mediated signaling pathway; negative chemotaxis; osteoblast differentiation; positive regulation of axon extension; regulation of inflammatory response

Disease: Blood Group, John Milton Hagen System