Rabbit anti-Human CCRL2 Polyclonal Antibody | anti-CCRL2 antibody

CCRL2, ID (CCRL2, CCR11, CCR6, CKRX, CRAM, HCR, C-C chemokine receptor-like 2, Chemokine receptor CCR11, Chemokine receptor X, Putative MCP-1 chemokine receptor) (APC)

Cat. Num. AAA6282653

• Gene Names: CCRL2; HCR; CKRX; CRAM; ACKR5; CCRL2; CRAM-A; CRAM-B
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: CCRL2; Polyclonal Antibody; ID (CCRL2; CCR11; CCR6; CKRX; CRAM; HCR; C-C chemokine receptor-like 2; Chemokine receptor CCR11; Chemokine receptor X; Putative MCP-1 chemokine receptor) (APC); Putative MCP-1 chemokine receptor; anti-CCRL2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-CCRL2 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: CCRL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 205-234 amino acids from the Central region of human CCRL2.
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(CCRL2 Antibody (Center) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the CCRL2 antibody detected the CCRL2 protein (arrow).)

Related Product Information for anti-CCRL2 antibody

This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located.

Product Categories/Family for anti-CCRL2 antibody

Antibodies; Receptors

References

Shimada, M., et al. Hum. Genet. 128(4):433-441(2010). Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010). Leick, M., et al. Immunology 129(4):536-546(2010). Segat, L., et al. Vaccine 28(10):2201-2206(2010). Zabel, B.A., et al. J. Exp. Med. 205(10):2207-2220(2008).

NCBI and Uniprot Product Information

• NCBI GI #: 68215224
• NCBI GeneID: 9034
• NCBI Accession #: NP_003956.2
• NCBI GenBank Nucleotide #: NM_003965.4
• UniProt Accession #: O00421; O75307; Q4VBB0; Q6IPX0; Q7KYQ9; Q96KP5; Q9UPG0; B4DKQ8
• Molecular Weight: 40,952 Da
• NCBI Official Full Name: C-C chemokine receptor-like 2 isoform 1
• NCBI Official Synonym Full Names: chemokine (C-C motif) receptor-like 2
• NCBI Official Symbol: CCRL2
• NCBI Official Synonym Symbols: HCR; CKRX; CRAM; ACKR5; CCRL2; CRAM-A; CRAM-B
• NCBI Protein Information: C-C chemokine receptor-like 2; chemokine receptor X; chemokine receptor CCR11; atypical chemokine receptor 5; putative MCP-1 chemokine receptor
• UniProt Protein Name: C-C chemokine receptor-like 2
• Protein Family: C-C chemokine receptor
• UniProt Gene Name: CCRL2
• UniProt Synonym Gene Names: CCR11; CCR6; CKRX; CRAM; HCR
• UniProt Entry Name: CCRL2_HUMAN

NCBI Description

This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located. [provided by RefSeq, Jul 2008]

Uniprot Description

CCRL2: Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: 3p21

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: CCR chemokine receptor binding; chemokine receptor binding; chemokine receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; chemotaxis; inflammatory response