Rabbit anti-Human CCR9 Polyclonal Antibody | anti-CCR9 antibody

CCR9 Antibody

Cat. Num. AAA9407346

• Gene Names: CCR9; GPR28; CDw199; GPR-9-6; CC-CKR-9
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: CCR9; Polyclonal Antibody; CCR9 Antibody; GPR28; CDw199; GPR-9-6; CC-CKR-9; anti-CCR9 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total CCR9 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 2.5 mg/ml (varies by lot)
• Sequence Length: 357

• Applicable Applications for anti-CCR9 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:50-1:200
• Immunogen Type: Recombinant Protein
• Immunogen Description: Fusion protein corresponding to a region derived from internal residues of human chemokine (C-C motif) receptor 9
• Target Name: CCR9
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue using at dilution 1/60.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/60.)

Related Product Information for anti-CCR9 antibody

The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene cluster region.

Product Categories/Family for anti-CCR9 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 373838705
• NCBI GeneID: 10803
• NCBI Accession #: NP_001243298.1
• NCBI GenBank Nucleotide #: NM_001256369.1
• UniProt Accession #: P51686; Q4VBM3; Q549E0; Q9UQQ6
• Molecular Weight: 40,713 Da
• NCBI Official Full Name: C-C chemokine receptor type 9 isoform B
• NCBI Official Synonym Full Names: chemokine (C-C motif) receptor 9
• NCBI Official Symbol: CCR9
• NCBI Official Synonym Symbols: GPR28; CDw199; GPR-9-6; CC-CKR-9
• NCBI Protein Information: C-C chemokine receptor type 9
• UniProt Protein Name: C-C chemokine receptor type 9
• Protein Family: C-C chemokine receptor
• UniProt Gene Name: CCR9
• UniProt Synonym Gene Names: GPR28; C-C CKR-9; CC-CKR-9; CCR-9
• UniProt Entry Name: CCR9_HUMAN

NCBI Description

The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Uniprot Description

CCR9: Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: cell surface; integral to plasma membrane; plasma membrane

Molecular Function: C-C chemokine receptor activity; chemokine receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; cellular defense response; immune response; chemotaxis