Goat anti-Murine CCR8 Polyclonal Antibody | anti-CCR8 antibody

CCR8 antibody

Cat. Num. AAA534084

• Gene Names: CCR8; CY6; TER1; CCR-8; CKRL1; CDw198; CMKBR8; GPRCY6; CMKBRL2; CC-CKR-8
• Reactivity: Murine
• Applications: ELISA, Immunohistochemistry, Western Blot
• Synonyms: CCR8; Polyclonal Antibody; CCR8 antibody; Polyclonal CCR8; Anti-CCR8; CC chemokine receptor 8; CCR-8; CCR 8; anti-CCR8 antibody

• Host: Goat
• Reactivity: Murine
• Clonality: Polyclonal
• Specificity: Murine
• Form/Format: 10mM KHPO4, pH 7.4, with 140mM NaCl, 1 mg/ml BSA and 0.1 % NaN3.
• Concentration: Typically 1-5 mg/ml (varies by lot)
• Sequence Length: 355

• Applicable Applications for anti-CCR8 antibody: ELISA (EIA), IC, Immmunohistochemistry (IHC), Western Blot (WB)
• Application Notes: ELISA: 1:50,000; IC: 1:200; IHC: 1:200; WB: 1:500
• Biological Significance: Chemokine receptors are G protein-coupled receptors (GPCRs) and play a key role in inflammation and are characterized by similar sequences with a 4 cysteine motif. Studies of CCR8 and its ligands suggest a role in regulation of monocyte chemotaxis and thymic cell apoptosis
• Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
• Immunogen: CCR8 antibody was raised in goat using a synthetic peptide PNVTMTDYYPDFFTAPCDAEFLLRGSM corresponding to amino acid residues 7-33 of mouse CCR8. as the immunogen.
• Preparation and Storage: Aliquot and store at -20 degree C for short term storage, -70 degree C for long-term storage. Avoid repeated freeze/thaw cycles.

Immunohistochemistry

(Immunohistochemical staining using CCR8 antibodyImmunohistochemistry on paraffin section of human spleen)

Related Product Information for anti-CCR8 antibody

Goat polyclonal CCR8 antibody

Product Categories/Family for anti-CCR8 antibody

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 4885121
• NCBI GeneID: 1237
• NCBI Accession #: NP_005192.1
• NCBI GenBank Nucleotide #: NM_005201.3
• UniProt Accession #: P51685; Q3KNQ8; Q3KNR3; Q9BYX5; B2RC64
• Molecular Weight: 31,622 Da
• NCBI Official Full Name: C-C chemokine receptor type 8
• NCBI Official Synonym Full Names: chemokine (C-C motif) receptor 8
• NCBI Official Symbol: CCR8
• NCBI Official Synonym Symbols: CY6; TER1; CCR-8; CKRL1; CDw198; CMKBR8; GPRCY6; CMKBRL2; CC-CKR-8
• NCBI Protein Information: C-C chemokine receptor type 8
• UniProt Protein Name: C-C chemokine receptor type 8
• Protein Family: C-C chemokine receptor
• UniProt Gene Name: CCR8
• UniProt Synonym Gene Names: CKRL1; CMKBR8; CMKBRL2; C-C CKR-8; CC-CKR-8; CCR-8; CKR-L1; GPRCY6
• UniProt Entry Name: CCR8_HUMAN

NCBI Description

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region. [provided by RefSeq, Jul 2008]

Uniprot Description

CCR8: Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3p22

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: C-C chemokine receptor activity; chemokine receptor activity; coreceptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; immune response; cell adhesion; chemotaxis