Rabbit anti-Human CCL21 Polyclonal Antibody | anti-CCL21 antibody

CCL21 antibody

Cat. Num. AAA9406899

• Gene Names: CCL21; ECL; SLC; CKb9; TCA4; 6Ckine; SCYA21
• Reactivity: Human
• Applications: Western Blot
• Purity: Antibodies were purified by affinity purification using immunogen.
• Synonyms: CCL21; Polyclonal Antibody; CCL21 antibody; ECL; SLC; CKb9; TCA4; 6Ckine; SCYA21; anti-CCL21 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total CCL21 antibody.
• Purity/Purification: Antibodies were purified by affinity purification using immunogen.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 134

• Applicable Applications for anti-CCL21 antibody: Western Blot (WB)
• Application Notes: Western blotting: 1:500 - 1:2000
• Immunogen Type: Recombinant Protein
• Immunogen Description: Recombinant protein of human CCL21.
• Target Name: CCL21
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts of Caco-2 cell lysate, using CCL21 antibody.)

Related Product Information for anti-CCL21 antibody

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19).

Product Categories/Family for anti-CCL21 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 4506835
• NCBI GeneID: 6366
• NCBI Accession #: NP_002980.1
• NCBI GenBank Nucleotide #: NM_002989.3
• UniProt Accession #: O00585
• Molecular Weight: 14,646 Da
• NCBI Official Full Name: C-C motif chemokine 21
• NCBI Official Synonym Full Names: chemokine (C-C motif) ligand 21
• NCBI Official Symbol: CCL21
• NCBI Official Synonym Symbols: ECL; SLC; CKb9; TCA4; 6Ckine; SCYA21
• NCBI Protein Information: C-C motif chemokine 21
• UniProt Protein Name: C-C motif chemokine 21
• Protein Family: C-C motif chemokine
• UniProt Gene Name: CCL21
• UniProt Synonym Gene Names: SCYA21; SLC
• UniProt Entry Name: CCL21_HUMAN

NCBI Description

This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19). [provided by RefSeq, Sep 2014]

Uniprot Description

CCL21: Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted; Motility/polarity/chemotaxis; Chemokine; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9p13

Cellular Component: extracellular space; extracellular region

Molecular Function: chemokine receptor binding; chemokine activity; CCR7 chemokine receptor binding

Biological Process: positive regulation of filopodium formation; positive regulation of I-kappaB kinase/NF-kappaB cascade; formation of immunological synapse; positive regulation of chemotaxis; positive regulation of dendritic cell antigen processing and presentation; cell maturation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of JNK cascade; positive regulation of cell adhesion mediated by integrin; positive regulation of receptor-mediated endocytosis; G-protein coupled receptor protein signaling pathway; positive regulation of protein kinase B signaling cascade; positive regulation of pseudopodium formation; positive regulation of actin filament polymerization; cell-cell signaling; positive regulation of protein kinase activity; release of sequestered calcium ion into cytosol; T cell costimulation; ruffle organization and biogenesis; dendritic cell chemotaxis; immune response; establishment of T cell polarity; positive regulation of cell-matrix adhesion; inflammatory response