Goat CCKBR / Cckb Polyclonal Antibody | anti-CCKBR antibody

Goat Polyclonal to Human CCKBR / Cckb

Cat. Num. AAA241980

• Gene Names: CCKBR; GASR; CCK-B; CCK2R
• Reactivity: Gibbon, Gorilla, Human, Orangutan
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: CCKBR / Cckb; Polyclonal Antibody; Goat Polyclonal to Human CCKBR / Cckb; Anti-CCKBR / Cckb Antibody (Internal) IHC-plus; CCKBR; CCKB; Cholecystokinin-2 receptor; CCK-BR; CCK2 receptor; CCK2-R; CCKB-R; Cholecystokinin-B; GASR; CCK-B; CCK-B receptor; CCK2R; Cckb receptor; CCKRB; Cholecystokinin B receptor; Gastrin receptor; Human CCKBR; Cckb; anti-CCKBR antibody

• Host: Goat
• Reactivity: Gibbon, Gorilla, Human, Orangutan
• Clonality: Polyclonal
• Specificity: Human CCKBR.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 447

• Applicable Applications for anti-CCKBR antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
• Application Notes: ELISA (1:32000), IHC-P (5 ug/ml), WB (0.1 - 0.3 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
• Target Species: Human
• Immunogen Description: Synthetic peptide C-FDGDSDSDSQSRVRNQ from an internal region of human CCKBR (NP_795344.1). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon (100%); Elephant (94%); Monkey, Hamster (88%); Marmoset, Mouse, Rabbit (81%).
• Immunogen Type: Synthetic peptide
• Immunogen: CCKBR / Cckb antibody was raised against synthetic peptide C-FDGDSDSDSQSRVRNQ from an internal region of human CCKBR (NP_795344.1). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon (100%); Elephant (94%); Monkey, Hamster (88%); Marmoset, Mouse, Rabbit (81%).
• Antigen Modification: Internal
• Preparation and Storage: Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-CCKBR antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Related Product Information for anti-CCKBR antibody

CCKB receptor, also called gastrin receptor, is a Cholecystokinin Receptor. CCKB receptor binds both sulfated and non-sulfated cholecystokinin analogs. This receptor regulates anxiety, arousal, opiate-induced analgesia, and gastric-acid secretion.

Product Categories/Family for anti-CCKBR antibody

Family: GPCR; Subfamily: Cholecystokinin

NCBI and Uniprot Product Information

• NCBI GI #: 28875799
• NCBI GeneID: 887
• NCBI Accession #: NP_795344.1
• NCBI GenBank Nucleotide #: NM_176875.3
• UniProt Accession #: P32239; O75824; Q16144; Q92492; Q96LC6; Q9NYK7; Q9UBV1; A8K7P9
• Molecular Weight: 41,504 Da
• NCBI Official Full Name: gastrin/cholecystokinin type B receptor
• NCBI Official Synonym Full Names: cholecystokinin B receptor
• NCBI Official Symbol: CCKBR
• NCBI Official Synonym Symbols: GASR; CCK-B; CCK2R
• NCBI Protein Information: gastrin/cholecystokinin type B receptor; CCK-BR; CCK2-R; CCK2 receptor; CCK-B receptor; gastrin receptor; cholecystokinin-2 receptor
• UniProt Protein Name: Gastrin/cholecystokinin type B receptor
• Protein Family: Gastrin/cholecystokinin type B receptor
• UniProt Gene Name: CCKBR
• UniProt Synonym Gene Names: CCKRB; CCK-B receptor; CCK-BR; CCK2-R
• UniProt Entry Name: GASR_HUMAN

NCBI Description

This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Jul 2008]

Uniprot Description

CCKBR: Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11p15.4

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: type B gastrin/cholecystokinin receptor binding; protein binding; gastrin receptor activity; 1-phosphatidylinositol-3-kinase regulator activity; cholecystokinin receptor activity; phosphoinositide phospholipase C activity

Biological Process: gland development; gastric acid secretion; metabolic process; regulation of phosphoinositide 3-kinase activity; cell proliferation; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; gut development; sensory perception; positive regulation of cell proliferation; digestion; feeding behavior; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)