Western Blot (WB)
(Western blot analysis of extracts from MCF-7 cells, using CBLL1 Antibody. The lane on the left was treated with blocking peptide.)
Rabbit CBLL1 Polyclonal Antibody | anti-CBLL1 antibody
CBLL1 Antibody
Predicted: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
Predicted: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
Western Blot (WB)
(Western blot analysis of extracts from MCF-7 cells, using CBLL1 Antibody. The lane on the left was treated with blocking peptide.)
Western Blot (WB)
(Western blot analysis of extracts from MCF-7 cells, using CBLL1 Antibody. The lane on the left was treated with blocking peptide.)
Subunit Structure: Homodimer. Interacts with tyrosine-phosphorylated SRC substrates. Component of the WTAP complex composed of WTAP, ZC3H13, CBLL1, VIRMA, RBM15, BCLAF1 and THRAP3 (PubMed:24100041).
Similarity: The HYB domain forms a phosphotyrosine-binding pocket upon dimerization, and mediates as well the recognition of its flanking acidic amino acids.
NCBI and Uniprot Product Information
Predicted: 55 kDa
NCBI Description
This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant. [provided by RefSeq, Aug 2011]
Uniprot Description
CBLL1: Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation.
Protein type: EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; EC 6.3.2.-; Cell adhesion; C2H2-type zinc finger protein; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 7q22.3
Cellular Component: ubiquitin ligase complex
Molecular Function: identical protein binding; protein binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activity
Biological Process: cell-cell adhesion; protein ubiquitination; positive regulation of endocytosis; negative regulation of cell adhesion; positive regulation of cell migration
Research Articles on CBLL1
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Product Notes
The CBLL1 cbll1 (Catalog #AAA9611328) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CBLL1 Antibody reacts with Human, Mouse, Rat Predicted: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus and may cross-react with other species as described in the data sheet. AAA Biotech's CBLL1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:2000. Researchers should empirically determine the suitability of the CBLL1 cbll1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CBLL1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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