Rabbit CBL Polyclonal Antibody | anti-CBL antibody
CBL Polyclonal Antibody
IHC: 1:50-1:200
ICC: 1:50-1:200
FC: 1:50-1:100
NCBI and Uniprot Product Information
NCBI Description
This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Jul 2016]
Uniprot Description
CBL: an adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling. Participates in signal transduction in hematopoietic cells.
Protein type: Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Oncoprotein; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component: cytosol; flotillin complex; lipid raft; plasma membrane
Molecular Function: cadherin binding; ephrin receptor binding; protein binding; receptor tyrosine kinase binding; SH3 domain binding; transcription factor activity; ubiquitin-protein ligase activity
Biological Process: cell surface receptor linked signal transduction; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; negative regulation of apoptosis; negative regulation of epidermal growth factor receptor activity; negative regulation of epidermal growth factor receptor signaling pathway; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of receptor-mediated endocytosis; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; transforming growth factor beta receptor signaling pathway
Disease: Juvenile Myelomonocytic Leukemia; Noonan Syndrome-like Disorder With Or Without Juvenile Myelomonocytic Leukemia
Research Articles on CBL
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Product Notes
The CBL cbl (Catalog #AAA2547543) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's CBL can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunoprecipitation (IP), Flow Cytometry (FC/FACS). WB: 1:500-1:2000 IHC: 1:50-1:200 ICC: 1:50-1:200 FC: 1:50-1:100. Researchers should empirically determine the suitability of the CBL cbl for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CBL, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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