Rabbit Cathepsin H Polyclonal Antibody | anti-Y205 antibody

Cathepsin H (Y205) Polyclonal Antibody

Cat. Num. AAA3003886

• Gene Names: CTSH; ACC4; ACC5; CPSB; ACC-4; ACC-5
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: Cathepsin H; Polyclonal Antibody; Cathepsin H (Y205) Polyclonal Antibody; Pro-cathepsin H; Cathepsin H; Cathepsin H heavy chain; CTSH; CPSB; CATH; anti-Y205 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Cathepsin H (Y205) polyclonal antibody detects endogenous levels of Cathepsin H protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 335

• Applicable Applications for anti-Y205 antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:200
• Immunogen: Synthetic peptide, corresponding to amino acids 171-210 of Human Cathepsin H.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry (IHC) analyzes of Cathepsin H (Y205) pAb in paraffin-embedded human colorectal carcinoma tissue at 1:50.)

Related Product Information for anti-Y205 antibody

The cathepsin family of proteolytic enzymes contains several diverse classes of proteases. The cysteine protease class comprises cathepsins B, L, H, K, S, and O. The aspartyl protease class is composed of cathepsins D and E. Cathepsin G is in the serine protease class. Most cathepsins are lysosomal and each is involved in various cellular events such as peptide biosynthesis and protein degradation. The propeptide region of cathepsin H is highly homologous to other cathepsins. This region is thought to play a role in the processing of cysteine proteases. Cathepsin H is thought to be involved in several pathological conditions, including neuro degenerative disorders and cancer.

NCBI and Uniprot Product Information

• NCBI GI #: 23110955
• NCBI GeneID: 1512
• NCBI Accession #: NP_004381.2
• NCBI GenBank Nucleotide #: NP_004381.2
• UniProt Accession #: P09668
• Molecular Weight: ~ 25, 37kDa
• NCBI Official Full Name: pro-cathepsin H isoform a preproprotein
• NCBI Official Synonym Full Names: cathepsin H
• NCBI Official Symbol: CTSH
• NCBI Official Synonym Symbols: ACC4; ACC5; CPSB; ACC-4; ACC-5
• NCBI Protein Information: pro-cathepsin H
• UniProt Protein Name: Pro-cathepsin H
• UniProt Gene Name: CTSH
• UniProt Synonym Gene Names: CPSB
• UniProt Entry Name: CATH_HUMAN

NCBI Description

The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

Uniprot Description

CTSH: Important for the overall degradation of proteins in lysosomes. Belongs to the peptidase C1 family.

Protein type: EC 3.4.22.16; Protease

Chromosomal Location of Human Ortholog: 15q25.1

Cellular Component: extracellular space; lysosome; acrosome; outer dense fiber; cytosol

Molecular Function: peptidase activity; protein binding; protein self-association; HLA-A specific activating MHC class I receptor activity; serine-type endopeptidase activity; cysteine-type endopeptidase activity; endopeptidase activity; protein complex binding; caspase activator activity; aminopeptidase activity; kininogen binding; cysteine-type peptidase activity

Biological Process: caspase activation; adaptive immune response; response to retinoic acid; protein destabilization; membrane protein proteolysis; proteolysis; antigen processing and presentation; positive regulation of angiogenesis; positive regulation of cell proliferation; zymogen activation; spermatogenesis; surfactant homeostasis; metanephros development; immune response-regulating signal transduction; positive regulation of cell migration; T cell mediated cytotoxicity; negative regulation of apoptosis