Rabbit CASQ2 Polyclonal Antibody | anti-CASQ2 antibody

CASQ2 Rabbit Polyclonal

Cat. Num. AAA767531

• Gene Names: CASQ2; PDIB2
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: CASQ2; Polyclonal Antibody; CASQ2 Rabbit Polyclonal; anti-CASQ2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 399

• Applicable Applications for anti-CASQ2 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Calsequestrin 2 (cardiac muscle)
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human heart tissue slide using MBS767531 (CASQ2 Antibody) at dilution of 1:200)

Western Blot (WB)

(human heart tissue were subjected to SDS PAGE followed by western blot with MBS767531 (CASQ2 antibody) at dilution of 1:500)

NCBI and Uniprot Product Information

• NCBI GI #: 119395727
• NCBI GeneID: 845
• NCBI Accession #: NP_001223.2
• NCBI GenBank Nucleotide #: NM_001232.3
• Molecular Weight: 38,269 Da
• NCBI Official Full Name: calsequestrin-2
• NCBI Official Synonym Full Names: calsequestrin 2
• NCBI Official Symbol: CASQ2
• NCBI Official Synonym Symbols: PDIB2
• NCBI Protein Information: calsequestrin-2
• UniProt Protein Name: Calsequestrin-2
• Protein Family: Calsequestrin
• UniProt Gene Name: CASQ2
• UniProt Entry Name: CASQ2_HUMAN

NCBI Description

The protein encoded by this gene specifies the cardiac muscle family member of the calsequestrin family. Calsequestrin is localized to the sarcoplasmic reticulum in cardiac and slow skeletal muscle cells. The protein is a calcium binding protein that stores calcium for muscle function. Mutations in this gene cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest. [provided by RefSeq, Jul 2008]

Uniprot Description

calsequestrin 2: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. The skeletal muscle isoform (CASQ1) binds around 80 Ca(2+) ions, while the cardiac isoform (CASQ2) binds approximately 60 Ca(2+) ions. Defects in CASQ2 are the cause of catecholaminergic polymorphic ventricular tachycardia type 2 (CPVT2); also known as stress-induced polymorphic ventricular tachycardia (VTSIP). CPVT2 is an autosomal recessive form of arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Belongs to the calsequestrin family.

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 1p13.1

Cellular Component: cytoplasm; intracellular; junctional membrane complex; sarcoplasmic reticulum; sarcoplasmic reticulum lumen; sarcoplasmic reticulum membrane; voltage-gated calcium channel complex; Z disc

Molecular Function: calcium ion binding; calcium-dependent protein binding; protein binding; protein homodimerization activity

Biological Process: cardiac muscle contraction; detection of calcium ion; negative regulation of potassium ion transport; protein polymerization; regulation of heart rate; sarcomere organization; sequestering of calcium ion; striated muscle contraction

Disease: Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/or Dilated Cardiomyopathy; Ventricular Tachycardia, Catecholaminergic Polymorphic, 2