Rabbit anti-Mouse Carnitine Palmitoyl Transferase 1, Liver Polyclonal Antibody | anti-CPT1C antibody

Carnitine Palmitoyl Transferase 1, Liver (CPT1-L)

Cat. Num. AAA625328

• Gene Names: CPT1C; CATL1; CPT1P; CPTIC; CPT1-B; CPTI-B; FLJ23809
• Reactivity: Mouse
• Applications: ELISA, Western Blot
• Purity: Serum; Serum
• Synonyms: Carnitine Palmitoyl Transferase 1; Liver; Polyclonal Antibody; Liver (CPT1-L); Anti -Carnitine Palmitoyl Transferase 1; anti-CPT1C antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes mouse Carnitine Palmitoyl Transferase 1, Liver (CPT1-L). No significant sequence homology is seen with MCPT-1, CPT-2 or any other protein.
• Purity/Purification: Serum; Serum
• Form/Format: Supplied as a liquid in PBS, 0.05% sodium azide.

• Applicable Applications for anti-CPT1C antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: Western Blot: 1:1000-1:5000; ELISA: 1:10,000-1:100,000 using 50-100ng of control peptide well.
• Immunogen: A 13-aa peptide sequence mapping near the C-terminus of mouse CPT1-L (KLH). Species sequence homology: rat 84% and human 69%.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-CPT1C antibody

In cells, excess of metabolic fuel is converted into fatty acids in cytosol and oxidized later in mitochondria to generate ATP and acetyl-CoA. In fatty acid synthesis, catalytic formation of malonyl-CoA (precursor for long-chain fatty acyl-CoA, LCFA-CoA) from acetyl-CoA by Acetyl-CoA carboxylase (ACC-1) is the rate limiting step. The translocation of LCFA-CoA from cytosol to mitochondria is catalyzed by two carnitine palmitoyl transferases (CPT-1 & CPT-2) and regulated by ACC-2, the rate limiting step of mitochondrial fatty acid b-oxidation. Activities of ACC-1 and 2 are regulated by their phosphorylation by 5'-AMPactivated protein kinase (AMPK). Diabetes deranges AMPK master-switch and represses the ACC-1 gene expression and stimulates excessive fatty acid oxidation which in turn interferes with glucose metabolism.

Product Categories/Family for anti-CPT1C antibody

Antibodies; Abs to Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 209862905
• NCBI GeneID: 126129
• NCBI Accession #: NP_001129524.1
• NCBI GenBank Nucleotide #: NM_001136052.2
• UniProt Accession #: Q59H75; Q8TCG5
• Molecular Weight: 45,251 Da
• NCBI Official Full Name: carnitine O-palmitoyltransferase 1, brain isoform isoform 1
• NCBI Official Synonym Full Names: carnitine palmitoyltransferase 1C
• NCBI Official Symbol: CPT1C
• NCBI Official Synonym Symbols: CATL1; CPT1P; CPTIC; CPT1-B; CPTI-B; FLJ23809
• NCBI Protein Information: carnitine O-palmitoyltransferase 1, brain isoform; carnitine palmitoyltransferase I related C; carnitine O-palmitoyltransferase I, brain isoform
• UniProt Protein Name: Carnitine palmitoyltransferase 1C variant
• Protein Family: Carnitine O-palmitoyltransferase
• UniProt Entry Name: Q59H75_HUMAN

NCBI Description

This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein regulates the beta-oxidation and transport of long-chain fatty acids into mitochondria, and may play a role in the regulation of feeding behavior and whole-body energy homeostasis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. [provided by RefSeq]

Uniprot Description

CPT1C: a member of the carnitine/choline acetyltransferase family. The encoded protein regulates the beta-oxidation and transport of long-chain fatty acids into mitochondria, and may play a role in the regulation of feeding behavior and whole-body energy homeostasis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

Protein type: EC 2.3.1.21; Membrane protein, integral; Lipid Metabolism - fatty acid; Transferase; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: endoplasmic reticulum membrane; mitochondrial outer membrane; synapse; cell junction

Molecular Function: carnitine O-palmitoyltransferase activity

Biological Process: fatty acid beta-oxidation; carnitine metabolic process

Disease: Spastic Paraplegia 73, Autosomal Dominant