Rabbit anti-Mouse, Rat CARD15 Polyclonal Antibody | anti-CARD15 antibody

CARD15 Antibody BIOTIN

Cat. Num. AAA5400556

• Gene Names: Nod2; CD; ACUG; BLAU; IBD1; Nlrc2; Card15; F830032C23Rik
• Reactivity: Mouse, Rat
• Applications: ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot
• Purity: Immobilized antigen affinity chromatography
• Synonyms: CARD15; Polyclonal Antibody; CARD15 Antibody BIOTIN; BIOTIN-Conjugated Nucleotide-binding oligomerization domain-containing protein 2 Antibody; ACUG antibody; Arthrocutaneouveal granulomatosis antibody; BLAU antibody; CARD15 antibody; Caspase recruitment domain protein 15 antibody; CD antibody; CLR16.3 antibody; IBD1 antibody; Inflammatory bowel disease protein 1 antibody; LRR containing protein antibody; NLR family; CARD domain containing 2 antibody; NLRC2 antibody; NOD like receptor C2 antibody; NOD2 antibody; NOD2B antibody; Nucleotide binding oligomerization domain; leucine rich repeat and CARD domain containing 2 antibody; PSORAS1 antibody; anti-CARD15 antibody

• Host: Rabbit
• Reactivity: Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Immobilized antigen affinity chromatography
• Concentration: 0.5-1.5 ug/ul in antibody stabilization buffer (varies by lot)
• Sequence Length: 1045

• Applicable Applications for anti-CARD15 antibody: ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
• Application Notes: ELISA: 1:50,000; IHC: 1:50-1:150; IP: 1:200; WB: 1:2,500-1:5,000
• Immunogen: Synthetic peptide taken within amino acid region 700-780 on mouse Nucleotide-binding oligomerization domain-containing protein 2.
• Conjugation: BIOTIN
• Molecular Function: actin binding ATP binding CARD domain binding endodeoxyribonuclease activity; producing 5'-phosphomonoesters enzyme binding Hsp70 protein binding; Hsp90 protein binding muramyl dipeptide binding peptidoglycan binding protein kinase binding
• Subcellular Location: Cytoplasm; Membrane; Basolateral cell membrane
• Preparation and Storage: Store at -20 degree C for long term storage.

Related Product Information for anti-CARD15 antibody

Overview: Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3 and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response (PubMed:22607974). Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561).

NCBI and Uniprot Product Information

• NCBI GI #: 28386271
• NCBI GeneID: 257632
• UniProt Accession #: Q8K3Z0
• Molecular Weight: 115,301 Da
• NCBI Official Full Name: Nod2 protein, partial
• NCBI Official Synonym Full Names: nucleotide-binding oligomerization domain containing 2
• NCBI Official Symbol: Nod2
• NCBI Official Synonym Symbols: CD; ACUG; BLAU; IBD1; Nlrc2; Card15; F830032C23Rik
• NCBI Protein Information: nucleotide-binding oligomerization domain-containing protein 2
• UniProt Protein Name: Nucleotide-binding oligomerization domain-containing protein 2
• UniProt Gene Name: Nod2
• UniProt Synonym Gene Names: Card15

Uniprot Description

Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response (PubMed:22607974). Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561). Component of an autophagy-mediated antibacterial pathway together with ATG16L1. Plays also a role in sensing single-stranded RNA (ssRNA) from viruses. Interacts with mitochondrial antiviral signaling/MAVS, leading to activation of interferon regulatory factor-3/IRF3 and expression of type I interferon.