Rabbit anti-Human, Mouse CAP1 Polyclonal Antibody | anti-CAP1 antibody

CAP1 (CAP, CAP 1, Adenylyl Cyclase-associated Protein 1) APC

Cat. Num. AAA6372158

• Gene Names: CAP1; CAP; CAP1-PEN
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: CAP1; Polyclonal Antibody; CAP1 (CAP; CAP 1; Adenylyl Cyclase-associated Protein 1) APC; anti-CAP1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human CAP1. Species Crossreactivity: mouse.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-CAP1 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full-length human CAP1, aa1-475 (NP_006358.1).
• Immunogen Sequence: MADMQNLVERLERAVGRLEAVSHTSDMHRGYADSPSKAGAAPYVQAFDSLLAGPVAEYLKISKEIGGDVQKHAEMVHTGLKLERALLVTASQCQQPAENKLSDLLAPISEQIKEVITFREKNRGSKLFNHLSAVSESIQALGWVAMAPKPGPYVKEMNDAAMFYTNRVLKEYKDVDKKHVDWVKAYLSIWTELQAYIKEFHTTGLAWSKTGPVAKELSGLPSGPSAGSGPPPPPPGPPPPPVSTSSGSDESASRSALFAQINQGESITHALKHVSDDMKTHKNPALKAQSGPVRSGPKPFSAPKPQTSPSPKRATKKEPAVLELEGKKWRVENQENVSNLVIEDTELKQVAYIYKCVNTTLQIKGKINSITVDNCKKLGLVFDDVVGIVEIINSKDVKVQVMGKVPTISINKTDGCHAYLSKNSLDCEIVSAKSSEMNVLIPTEGGDFNEFPVPEQFKTLWNGQKLVTTVTEIAG
• Conjugate: APC
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(CAP1 rabbit polyclonal antibody. Western Blot analysis of CAP1 expression in human pancreas.)

Western Blot (WB)

(CAP1 rabbit polyclonal antibody. Western Blot analysis of CAP1 expression in mouse spleen.)

Western Blot (WB)

(CAP1 rabbit polyclonal antibody. Western Blot analysis of CAP1 expression in HepG2.)

Western Blot (WB)

(Western Blot analysis of CAP1 expression in transfected 293T cell line by CAP1 polyclonal antibody. Lane 1: CAP1 transfected lysate (51.7kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-CAP1 antibody

CAP is related to the S. cerevisiae CAP protein, which is involved in the cyclic AMP pathway. The human protein is able to interact with other molecules of the same protein, as well as with CAP2 and actin.

Product Categories/Family for anti-CAP1 antibody

Antibodies; Enzymes; Cyclase

NCBI and Uniprot Product Information

• NCBI GI #: 5453595
• NCBI GeneID: 10487
• NCBI Accession #: NP_006358.1
• NCBI GenBank Nucleotide #: NM_006367
• UniProt Accession #: Q01518; Q53HR7; Q5T0S1; Q5T0S2; Q6I9U6
• Molecular Weight: 51,830 Da
• NCBI Official Full Name: adenylyl cyclase-associated protein 1 isoform a
• NCBI Official Synonym Full Names: cyclase associated actin cytoskeleton regulatory protein 1
• NCBI Official Symbol: CAP1
• NCBI Official Synonym Symbols: CAP; CAP1-PEN
• NCBI Protein Information: adenylyl cyclase-associated protein 1
• UniProt Protein Name: Adenylyl cyclase-associated protein 1
• Protein Family: CAP1-binding-protein
• UniProt Gene Name: CAP1
• UniProt Synonym Gene Names: CAP; CAP 1
• UniProt Entry Name: CAP1_HUMAN

NCBI Description

The protein encoded by this gene is related to the S. cerevisiae CAP protein, which is involved in the cyclic AMP pathway. The human protein is able to interact with other molecules of the same protein, as well as with CAP2 and actin. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2016]

Uniprot Description

CAP1: an actin binding protein. Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.

Protein type: Actin-binding; Cytoskeletal

Chromosomal Location of Human Ortholog: 1p34.2

Cellular Component: cortical actin cytoskeleton; focal adhesion; plasma membrane

Molecular Function: actin binding

Biological Process: axon guidance; platelet activation; receptor-mediated endocytosis; platelet degranulation; ameboidal cell migration; adenylate cyclase activation; establishment and/or maintenance of cell polarity; signal transduction; blood coagulation; actin cytoskeleton organization and biogenesis