Rabbit anti-Human, Mouse CANT1 Polyclonal Antibody | anti-CANT1 antibody

CANT1 Antibody

Cat. Num. AAA9604104

• Gene Names: CANT1; DBQD; EDM7; DBQD1; SCAN1; SHAPY; SCAN-1
• Reactivity: Human, Mouse
• Applications: Western Blot, ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
• Synonyms: CANT1; Polyclonal Antibody; CANT1 Antibody; Apyrase; Apyrase homolog; Ca2+ dependent endoplasmic reticulum nucleoside diphosphatase; Calcium activated nucleotidase 1; CANT 1; CANT1_HUMAN; Putative MAPK activating protein PM09; Putative MAPK-activating protein PM09; Putative NF kappa B activating protein 107; Putative NF-kappa-B-activating protein 107; SCAN 1; SCAN-1; SHAPY; Soluble Ca activated nucleotidase isozyme 1; Soluble calcium activated nucleotidase 1; Soluble calcium activated nucleotidase SCAN 1; Soluble calcium-activated nucleotidase 1; anti-CANT1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: CANT1 antibody detects endogenous levels of total CANT1
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
• Form/Format: Liquid; Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)
• Sequence Length: 401

• Applicable Applications for anti-CANT1 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500-1:2000
• Immunogen: A synthesized peptide
• Subcellular Location: Endoplasmic Reticulum Membrane. Golgi Apparatus > Golgi Stack Membrane. Processed form: Secreted.
• Tissue Specificity: Widely expressed.
• Predicted Cross Reactivity: Pig, Bovine, Horse, Rabbit, Dog, Chicken, Xenopus
• Similarity: Pig (90%), Bovine (90%), Horse (90%), Rabbit (90%), Dog (90%), Chicken (100%), Xenopus (90%)
• Conjugation: Unconjugated

Western Blot (WB)

(Western blot analysis of CANT1 expression in Jurkat cell line lysates, The lane on the left is treated with the antigen-specific peptide.)

Related Product Information for anti-CANT1 antibody

Function: Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP (PubMed:12234496, PubMed:15248776, PubMed:15006348, PubMed:16835225). Involved in proteoglycan synthesis (PubMed:22539336).
Subunit Structure: Monomer (PubMed:12234496, PubMed:15006348). Homodimer; dimerization is Ca2+-dependent (PubMed:16835225). Homodimer; disulfide-linked (membrane form) (PubMed:16835225).
Post-translational Modifications: N-glycosylated.
Similarity: Belongs to the apyrase family.

NCBI and Uniprot Product Information

• NCBI GI #: 229577440
• NCBI GeneID: 124583
• NCBI Accession #: NP_001153244.1
• NCBI GenBank Nucleotide #: NM_001159772.1
• UniProt Accession #: Q8WVQ1; Q7Z2J7; Q8NG05; Q8NHP0; Q9BSD5; B4DJ54
• Molecular Weight: Observed: 45 kDa; Predicted: 45 kDa
• NCBI Official Full Name: soluble calcium-activated nucleotidase 1
• NCBI Official Synonym Full Names: calcium activated nucleotidase 1
• NCBI Official Symbol: CANT1
• NCBI Official Synonym Symbols: DBQD; EDM7; DBQD1; SCAN1; SHAPY; SCAN-1
• NCBI Protein Information: soluble calcium-activated nucleotidase 1
• UniProt Protein Name: Soluble calcium-activated nucleotidase 1
• Protein Family: Soluble calcium-activated nucleotidase
• UniProt Gene Name: CANT1
• UniProt Synonym Gene Names: SHAPY; SCAN-1

NCBI Description

This protein encoded by this gene belongs to the apyrase family. It functions as a calcium-dependent nucleotidase with a preference for UDP. Mutations in this gene are associated with Desbuquois dysplasia with hand anomalies. Alternatively spliced transcript variants have been noted for this gene.[provided by RefSeq, Mar 2010]

Uniprot Description

Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP (PubMed:12234496, PubMed:15248776, PubMed:15006348, PubMed:16835225). Involved in proteoglycan synthesis (PubMed:22539336).