Western Blot (WB)
(Western blot analysis CAMKK1/2 (Phospho-Ser458/495) using EGF treated 293 whole cell lysates)
Rabbit CAMKK1/2 Polyclonal Antibody | anti-CAMKK1/2 antibody
CAMKK1/2 (Phospho-Ser458/495) Antibody
Western Blot (WB)
(Western blot analysis CAMKK1/2 (Phospho-Ser458/495) using EGF treated 293 whole cell lysates)
Western Blot (WB)
(Western blot analysis CAMKK1/2 (Phospho-Ser458/495) using EGF treated 293 whole cell lysates)
NCBI and Uniprot Product Information
NCBI Description
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
CAMKK1: a calcium/calmodulin-dependent S/T protein kinase of the CAMKK family. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. 2 isoforms of the human protein are produced by alternative splicing. The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition. Binding of calmodulin may releave intrasteric autoinhibition. May be regulated through phosphorylation by CAMK1 and CAMK4. Appears to be autophosphorylated in a Ca2+/calmodulin-dependent manner. Phosphorylation of Ser-458 is blocked upon binding to Ca2+/calmodulin.
Protein type: CAMKK family; EC 2.7.11.17; Kinase, protein; Meta subfamily; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 17p13.2
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: calmodulin binding; calmodulin-dependent protein kinase activity; protein binding
Biological Process: peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of protein kinase activity
Research Articles on CAMKK1/2
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Product Notes
The CAMKK1/2 camkk1 (Catalog #AAA9416580) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CAMKK1/2 (Phospho-Ser458/495) Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CAMKK1/2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1:1000. Researchers should empirically determine the suitability of the CAMKK1/2 camkk1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CAMKK1/2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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