Sheep anti-Human Calsyntenin-2 Polyclonal Antibody | anti-CLSTN2 antibody

Calsyntenin-2 (Calsyntenin 2, Alcadein-gamma, Alc-gamma, CLSTN2, CS2)

Cat. Num. AAA6012390

• Gene Names: CLSTN2; CS2; CSTN2; CDHR13; ALC-GAMMA; alcagamma
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Calsyntenin-2; Polyclonal Antibody; Calsyntenin-2 (Calsyntenin 2; Alcadein-gamma; Alc-gamma; CLSTN2; CS2); Anti -Calsyntenin-2 (Calsyntenin 2; anti-CLSTN2 antibody

• Host: Sheep
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human Calsyntenin-2. Species sequence homology: human Calsyntenin-1 and Calsyntenin-3 (1%).
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 200ug/ml.

• Applicable Applications for anti-CLSTN2 antibody: Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Immunohistochemistry.; Dilution: Immunohistochemistry: 5-15ug/ml
• Immunogen: Recombinant corresponding to aa21-834 from Calsyntenin-2 expressed in NSO cells (Q9H4D0).
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-CLSTN2 antibody

Calsyntenin-2 (CS-2) is a 120-135kD member of the Alcadein family of molecules. It is expressed in the ER/Golgi, and the plasma membranes of almost all neurons. It is a calcium-binding protein that interacts with APP and X11L. In this regard, it appears to regulate APP cleavage and gene activation, and likely impacts post-synaptic signaling. Notably, when cleaved in a manner similar to APP, its intracellular fragment antagonizes AICD gene activation. Mature human CS-2 is a 935aa type I transmembrane protein. It contains two cadherin domains aa44-280 in its extracellular region aa21-831 and a 103aa cytoplasmic tail. Proteolytic cleavage by ADAM10 occurs between His803 and Leu804 to generate a 105-110kD extracellular fragment. Additional processing of the transmembrane fragment by g-secretase creates a 3kD fragment aa804-834 plus a 25kD cytoplasmic protein. Potential isoform variants show a premature truncation after Gln608, and the use of an alternative start site at Met409. Over aa21-834, human CS-2 shares 95aa identity with mouse CST-2.

Product Categories/Family for anti-CLSTN2 antibody

Antibodies; Abs to Neuroscience

NCBI and Uniprot Product Information

• NCBI GI #: 209364544
• NCBI GeneID: 64084
• NCBI Accession #: NP_071414.2
• NCBI GenBank Nucleotide #: NM_022131.2
• UniProt Accession #: Q9H4D0; Q3SX54; Q3ZB76; Q5UE56; Q96HZ2; Q9BSS0; B2RCW5; D3DNF4
• Molecular Weight: 107,006 Da
• NCBI Official Full Name: calsyntenin-2
• NCBI Official Synonym Full Names: calsyntenin 2
• NCBI Official Symbol: CLSTN2
• NCBI Official Synonym Symbols: CS2; CSTN2; CDHR13; ALC-GAMMA; alcagamma
• NCBI Protein Information: calsyntenin-2; alcadein gamma; alcadein-gamma; cadherin-related family member 13
• UniProt Protein Name: Calsyntenin-2
• Protein Family: Calsyntenin
• UniProt Gene Name: CLSTN2
• UniProt Synonym Gene Names: CS2; Alc-gamma
• UniProt Entry Name: CSTN2_HUMAN

Uniprot Description

CLSTN2: May modulate calcium-mediated postsynaptic signals.

Protein type: Inhibitor; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q23

Cellular Component: Golgi membrane; postsynaptic membrane; endoplasmic reticulum membrane; integral to membrane

Molecular Function: calcium ion binding

Biological Process: homophilic cell adhesion