Rabbit anti-Mouse Calpain 10 (CAPN10) Polyclonal Antibody | anti-CAPN10 antibody

HRP-Linked Polyclonal Antibody to Calpain 10 (CAPN10)

Cat. Num. AAA2069151

• Gene Names: CAPN10; CANP10; NIDDM1
• Reactivity: Mouse
• Applications: Western Blot, Immunocytochemistry, Immunohistochemistry, ELISA
• Synonyms: Calpain 10 (CAPN10); Polyclonal Antibody; HRP-Linked Polyclonal Antibody to Calpain 10 (CAPN10); Calcium-activated neutral proteinase 10; anti-CAPN10 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Concentration: 500ug/ml (varies by lot)

• Applicable Applications for anti-CAPN10 antibody: Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)
• Immunogen: CAPN10 (Ser22~Pro374)
• Conjugation: HRP
• Cross Reactivity: Mouse
• Unconjugated Antibody: The unconjugated antibody version of this item is also available as catalog #MBS2026531

NCBI and Uniprot Product Information

• NCBI GI #: 37589919
• NCBI GeneID: 11132
• Molecular Weight: 15,275 Da
• NCBI Official Full Name: Calpain 10
• NCBI Official Synonym Full Names: calpain 10
• NCBI Official Symbol: CAPN10
• NCBI Official Synonym Symbols: CANP10; NIDDM1
• NCBI Protein Information: calpain-10
• UniProt Protein Name: Calpain-10
• Protein Family: Calpain
• UniProt Gene Name: CAPN10
• UniProt Synonym Gene Names: KIAA1845; CANP 10

NCBI Description

Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq, Sep 2010]

Uniprot Description

CAPN10: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Defects in CAPN10 are a cause of susceptibility to diabetes mellitus non-insulin-dependent type 1 (NIDDM1). It is a multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. Belongs to the peptidase C2 family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; EC 3.4.22.-; Mitochondrial; Protease

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: cell; cytosol; mitochondrion; plasma membrane

Molecular Function: calcium-dependent cysteine-type endopeptidase activity; cytoskeletal protein binding; SNARE binding

Biological Process: actin cytoskeleton reorganization; cell structure disassembly during apoptosis; cellular response to insulin stimulus; positive regulation of glucose import; positive regulation of insulin secretion; positive regulation of intracellular transport; proteolysis

Disease: Diabetes Mellitus, Noninsulin-dependent, 1