Rabbit anti-Human Calpain-1 catalytic subunit Polyclonal Antibody | anti-CAPN1 antibody

Rabbit anti-human Calpain-1 catalytic subunit polyclonal Antibody(CAPN1), HRP conjugated

Cat. Num. AAA1493395

• Gene Names: CAPN1; CANP; muCL; CANP1; CANPL1; muCANP
• Reactivity: Human
• Applications: ELISA
• Purity: Caprylic Acid Ammonium Sulfate Precipitation Purified
• Synonyms: Calpain-1 catalytic subunit; Polyclonal Antibody; Rabbit anti-human Calpain-1 catalytic subunit polyclonal Antibody(CAPN1); HRP conjugated; Calcium-activated neutral proteinase 1; Calpain mu-type; Calpain-1 large subunit; Cell proliferation-inducing gene 30 protein; Micromolar-calpain; muCANP; CAPN1; CANPL1; PIG30; anti-CAPN1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Caprylic Acid Ammonium Sulfate Precipitation Purified
• Sequence Length: 714

• Applicable Applications for anti-CAPN1 antibody: ELISA (EIA)
• Storage Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Conjugate: HRP
• Immunogen: Recombinant human Calpain-1 catalytic subunit protein(1-714AA)
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-7531 / sc-31066 / sc-31065 / sc-7530 / sc-13990
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Related Product Information for anti-CAPN1 antibody

Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

NCBI and Uniprot Product Information

• NCBI GI #: 311893363
• NCBI GeneID: 823
• NCBI Accession #: NP_001185797.1
• NCBI GenBank Nucleotide #: NM_001198868.1
• UniProt Accession #: P07384; Q2TTR0; Q6DHV4
• Molecular Weight: 81,890 Da
• NCBI Official Full Name: calpain-1 catalytic subunit
• NCBI Official Synonym Full Names: calpain 1
• NCBI Official Symbol: CAPN1
• NCBI Official Synonym Symbols: CANP; muCL; CANP1; CANPL1; muCANP
• NCBI Protein Information: calpain-1 catalytic subunit
• UniProt Protein Name: Calpain-1 catalytic subunit
• Protein Family: Calpain
• UniProt Gene Name: CAPN1
• UniProt Synonym Gene Names: CANPL1; CANP 1; muCANP
• UniProt Entry Name: CAN1_HUMAN

NCBI Description

The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Uniprot Description

CAPN1: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Forms a heterodimer with a small (regulatory) subunit (CAPNS1). Ubiquitous. Activated by micromolar concentrations of calcium and inhibited by calpastatin. Belongs to the peptidase C2 family.

Protein type: Motility/polarity/chemotaxis; EC 3.4.22.52; Protease

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: cytoplasm; cytosol; focal adhesion; lysosome; membrane; mitochondrion; plasma membrane

Molecular Function: calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; cytoskeletal protein binding; protein binding

Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; mammary gland involution; positive regulation of cell proliferation; proteolysis; receptor catabolic process