Rabbit CACNG1 Polyclonal Antibody | anti-CACNG1 antibody

CACNG1 Polyclonal Antibody

Cat. Num. AAA3005964

• Gene Names: CACNG1; CACNLG
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: CACNG1; Polyclonal Antibody; CACNG1 Polyclonal Antibody; Voltage-dependent calcium channel gamma-1 subunit; Dihydropyridine-sensitive L-type; skeletal muscle calcium channel subunit gamma; CACNLG; L-type Ca++ CP gamma1; L-type Ca++ CPgamma1; anti-CACNG1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: CACNG1 polyclonal antibody detects endogenous levels of CACNG1 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 222

• Applicable Applications for anti-CACNG1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: Synthetic peptide, corresponding to the 177-222 of Human CACNG1.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of CACNG1 polyclonal antibody at 1:500 dilutionLane1:Hela cell lysateLane2:sp2/0 cell lysateLane3:H9C2 cell lysate)

Related Product Information for anti-CACNG1 antibody

Voltage-dependent calcium channels are essential for the release of neurotransmitters. L-type (long lasting current) voltage-dependent calcium channels are composed of four subunits: an alpha1 subunit, a beta subunit, a gamma subunit and an alpha2delta subunit. The beta subunit is encoded by four genes, designated beta1-beta4, all of which contribute to the diversity of calcium currents and are involved in membrane trafficking of the alpha1 subunit. L-type Ca ++ CP gamma1, also known as CACNLG or CACNG1, is a 222 amino acid multi-pass membrane protein belonging to the PMP-22/EMP/MP20 family. Expressed in skeletal muscle, L-type Ca ++ CP gamma1 is a subunit of the dihydropyridine (DHP) sensitive calcium channel and may play a role in excitation-contraction coupling. L-type Ca++ CP gamma1 is considered a novel marker for malignant hyperthermia susceptibility (MHS), an autosomal dominant disorder of skeletal muscle which manifests as a life-threatening hypermetabolic crisis triggered by commonly used inhalation anaesthetics and depolarizing muscle relaxants.

NCBI and Uniprot Product Information

• NCBI GI #: 4502539
• NCBI GeneID: 786
• NCBI Accession #: NP_000718.1
• NCBI GenBank Nucleotide #: NP_000718.1
• UniProt Accession #: Q06432
• Molecular Weight: ~ 25kDa
• NCBI Official Full Name: voltage-dependent calcium channel gamma-1 subunit
• NCBI Official Synonym Full Names: calcium voltage-gated channel auxiliary subunit gamma 1
• NCBI Official Symbol: CACNG1
• NCBI Official Synonym Symbols: CACNLG
• NCBI Protein Information: voltage-dependent calcium channel gamma-1 subunit
• UniProt Protein Name: Voltage-dependent calcium channel gamma-1 subunit
• Protein Family: Voltage-dependent calcium channel
• UniProt Gene Name: CACNG1
• UniProt Synonym Gene Names: CACNLG
• UniProt Entry Name: CCG1_HUMAN

NCBI Description

Voltage-dependent calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of two known gamma subunit proteins. This particular gamma subunit is part of skeletal muscle 1,4-dihydropyridine-sensitive calcium channels and is an integral membrane protein that plays a role in excitation-contraction coupling. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members that function as transmembrane AMPA receptor regulatory proteins (TARPs). [provided by RefSeq, Dec 2010]

Uniprot Description

CACNG1: This protein is a subunit of the dihydropyridine (DHP) sensitive calcium channel. Plays a role in excitation-contraction coupling. The skeletal muscle DHP-sensitive Ca(2+) channel may function only as a multiple subunit complex. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q24

Cellular Component: voltage-gated calcium channel complex

Molecular Function: voltage-gated calcium channel activity

Biological Process: muscle contraction; transport