Western Blot (WB)
(Host: RabbitTarget Name: CACNA2D4Sample Type: A549 Whole Cell lysatesAntibody Dilution: 1.0ug/ml)
Rabbit CACNA2D4 Polyclonal Antibody | anti-CACNA2D4 antibody
CACNA2D4 Antibody - middle region
Western Blot (WB)
(Host: RabbitTarget Name: CACNA2D4Sample Type: A549 Whole Cell lysatesAntibody Dilution: 1.0ug/ml)
Western Blot (WB)
(Host: RabbitTarget Name: CACNA2D4Sample Type: A549 Whole Cell lysatesAntibody Dilution: 1.0ug/ml)
Target Description: This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Uniprot Description
CACNA2D4: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Defects in CACNA2D4 are the cause of retinal cone dystrophy 4 (RCD4). RCD4 is characterized by minimal symptoms except for slowly progressive reduction in visual acuity. Belongs to the calcium channel subunit alpha-2/delta family. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Channel, calcium
Chromosomal Location of Human Ortholog: 12p13.33
Cellular Component: voltage-gated calcium channel complex
Molecular Function: voltage-gated calcium channel activity; metal ion binding
Biological Process: detection of light stimulus involved in visual perception
Disease: Retinal Cone Dystrophy 4
Research Articles on CACNA2D4
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Product Notes
The CACNA2D4 cacna2d4 (Catalog #AAA3216843) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CACNA2D4 Antibody - middle region reacts with Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CACNA2D4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the CACNA2D4 cacna2d4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: ADLNHEFNES LVFDYYNSVL INERDEKGNF VELGAEFLLE SNAHFSNLPV. It is sometimes possible for the material contained within the vial of "CACNA2D4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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