Rabbit anti-Human C5AR2 Polyclonal Antibody | anti-C5AR2 antibody

C5AR2 Polyclonal Antibody

Cat. Num. AAA2559903

• Gene Names: C5AR2; C5L2; GPF77; GPR77
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA
• Purity: Antigen Affinity Purification
• Synonyms: C5AR2; Polyclonal Antibody; C5AR2 Polyclonal Antibody; C5a anaphylatoxin chemotactic receptor C5L2; C5ARL; C5L2; E030029A11Rik; G protein coupled receptor 77; G protein coupled receptor C5L2; G-protein coupled receptor 77; GPF77; GPR77; anti-C5AR2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purification
• Form/Format: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
• Concentration: 0.66mg/mL (varies by lot)
• Sequence Length: 337

• Applicable Applications for anti-C5AR2 antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:30-1:150; ELISA: 1:5000-1:10000
• Immunogen: Synthetic peptide of human C5AR2
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using C5AR2 Polyclonal Antibody at dilution of 1:25(×200))

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using C5AR2 Polyclonal Antibody at dilution of 1:25(×200))

Related Product Information for anti-C5AR2 antibody

This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. 

Product Categories/Family for anti-C5AR2 antibody

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 8923873
• NCBI GeneID: 27202
• NCBI Accession #: NP_060955.1
• NCBI GenBank Nucleotide #: NP_060955.1
• UniProt Accession #: Q9P296
• NCBI Official Full Name: C5a anaphylatoxin chemotactic receptor 2
• NCBI Official Synonym Full Names: complement component 5a receptor 2
• NCBI Official Symbol: C5AR2
• NCBI Official Synonym Symbols: C5L2; GPF77; GPR77
• NCBI Protein Information: C5a anaphylatoxin chemotactic receptor 2
• UniProt Protein Name: C5a anaphylatoxin chemotactic receptor 2
• Protein Family: C5a anaphylatoxin chemotactic receptor
• UniProt Gene Name: C5AR2
• UniProt Synonym Gene Names: C5L2; GPR77
• UniProt Entry Name: C5AR2_HUMAN

NCBI Description

This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Uniprot Description

C5AR2: Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: apical part of cell; integral to membrane; plasma membrane; basal plasma membrane

Molecular Function: protein binding; C5a anaphylatoxin receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of tumor necrosis factor production; inflammatory response; chemotaxis; positive regulation of epithelial cell proliferation