Rabbit C1D Polyclonal Antibody | anti-C1D antibody

C1D Polyclonal Antibody

Cat. Num. AAA3011578

• Gene Names: C1D; LRP1; hC1D; Rrp47; SUNCOR; SUN-CoR
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunofluorescence
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: C1D; Polyclonal Antibody; C1D Polyclonal Antibody; 1110036E10Rik; AI875855; C1D DNA binding protein; C1D_HUMAN; hC1D; LRP1; MGC12261; MGC14659; MGC188504; Nuclear DNA binding protein; Nuclear nucleic acid binding protein C1D; Nuclear nucleic acid-binding protein C1D; rCG23324; RGD1560600; Small unique nuclear receptor corepressor; SUNCOR; anti-C1D antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: C1D polyclonal antibody detects endogenous levels of C1D protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 141

• Applicable Applications for anti-C1D antibody: Western Blot (WB), Immunofluorescence (IF)
• Application Notes: WB: 1:500-1:2000; IF: 1:50-1:200
• Immunogen: Recombinant full length Human C1D.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Immunofluorescence (IF)

(Immunofluorescence analysis of HeLa cells using C1D antibody.)

Related Product Information for anti-C1D antibody

C1D, also known as SUNCOR, is a nuclear DNA-binding protein that localizes to the nucleus and cytoplasm and participates in processing of the 5.8S rRNA. Expressed ubiquitously with highest expression in thyroid, salivary gland, hippocampus and medulla oblongata, C1D forms a multi-protein complex with MPP6 (M phase phosphoprotein 6) and EXOSC10 (exosome component 10). This complex is responsible, in part, for recruiting the exosome to pre-rRNA and it functions to mediate 3-5 rRNA processing. Additionally, C1D can induce transcriptional repression and apoptosis through interaction with Rev-erbalpha (V-erbA-related protein EAR-1)/TRbeta (thyroid hormone receptor beta) and p53, respectively. C1D, a 141 amino acid protein, is also implicated in DNA repair mechanisms, as well as DNA-PK (DNA-dependent protein kinase) activation.

NCBI and Uniprot Product Information

• NCBI GI #: 298231253
• NCBI GeneID: 10438
• NCBI Accession #: NP_001177192.1
• NCBI GenBank Nucleotide #: NP_001177192.1
• UniProt Accession #: Q13901
• Molecular Weight: ~ 16kDa
• NCBI Official Full Name: nuclear nucleic acid-binding protein C1D
• NCBI Official Synonym Full Names: C1D nuclear receptor corepressor
• NCBI Official Symbol: C1D
• NCBI Official Synonym Symbols: LRP1; hC1D; Rrp47; SUNCOR; SUN-CoR
• NCBI Protein Information: nuclear nucleic acid-binding protein C1D
• UniProt Protein Name: Nuclear nucleic acid-binding protein C1D
• Protein Family: Nuclear nucleic acid-binding protein
• UniProt Gene Name: C1D
• UniProt Synonym Gene Names: hC1D
• UniProt Entry Name: C1D_HUMAN

NCBI Description

The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Alternate splicing results in multiple transcript variants that encode the same protein. Multiple pseudogenes of this gene are found on chromosome 10.[provided by RefSeq, Jun 2010]

Uniprot Description

C1D: Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB. Belongs to the C1D family.

Protein type: Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor; DNA-binding

Chromosomal Location of Human Ortholog: 2p13-p12

Cellular Component: transcriptional repressor complex; cytoplasm; nucleolus; nucleus; nuclear exosome (RNase complex)

Molecular Function: ligand-dependent nuclear receptor binding; protein binding; DNA binding; RNA binding; transcription corepressor activity

Biological Process: maturation of 5.8S rRNA; transcription, DNA-dependent; apoptosis; negative regulation of transcription, DNA-dependent