Rabbit anti-Human, Rat C15orf42 Polyclonal Antibody | anti-TICRR antibody
C15orf42 Antibody FITC-Conjugated
ELISA: 1:10,000
Western Blot: 1:500
Regulates triggering of DNA replication onto replication origins, required for transition from pre-replication complex to pre-initiation complex. Required to prevent mitotic entry after treatment with ionizing radiation.
NCBI and Uniprot Product Information
NCBI Description
Treslin is involved in the initiation of DNA replication (Kumagai et al., 2010 [PubMed 20116089]).[supplied by OMIM, Apr 2010]
Uniprot Description
TICRR: Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre- initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. Belongs to the treslin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA replication; Cell cycle regulation
Chromosomal Location of Human Ortholog: 15q26.1
Cellular Component: nucleoplasm; nucleus
Molecular Function: chromatin binding; protein binding
Biological Process: cell cycle checkpoint; DNA repair; DNA replication; formation of translation preinitiation complex; mitotic cell cycle DNA replication checkpoint; regulation of DNA replication initiation; response to ionizing radiation
Research Articles on TICRR
Similar Products
Product Notes
The TICRR ticrr (Catalog #AAA5400182) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The C15orf42 Antibody FITC-Conjugated reacts with Human, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's C15orf42 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Dot Blot: 1:10,000 ELISA: 1:10,000 Western Blot: 1:500. Researchers should empirically determine the suitability of the TICRR ticrr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "C15orf42, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
