Goat C-REACTIVE PROTEIN Polyclonal Antibody | anti-CRP antibody

GOAT ANTI HUMAN C-REACTIVE PROTEIN

Cat. Num. AAA223278

• Gene Names: CRP; PTX1
• Applications: ELISA, Immunodiffusion
• Synonyms: C-REACTIVE PROTEIN; Polyclonal Antibody; GOAT ANTI HUMAN C-REACTIVE PROTEIN; anti-CRP antibody

• Host: Goat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: This item is specific for human C-reactive protein (CRP), a calcium-binding acute phase reactant belonging to the pentraxin family which is secreted into the plasma by the liver, in response to cytokine stimulation. ; ; In addition to binding to phosphocholine residues, CRP can bind to other autologous and extrinsic ligands on targets, including damaged cell membranes, ribonucleoprotein particles, apoptotic cells and constituents of micro-organisms, and may activate the classical complement pathway through C1q recognition, making CRP a factor in a variety of host defense mechanisms. Levels of plasma CRP are significantly increased during the acute phase response, tissue injury and infection and can be used as a marker of inflammation, disease progress and risk assessment of cardiovascular disease (CVD).
• Form/Format: Purified; Purified IgG - liquid
• Concentration: IgG concentration 5.0mg/ml (varies by lot)
• Sequence Length: 224

• Applicable Applications for anti-CRP antibody: ELISA (EIA), Immunodiffusion (ID)
• Application Notes: ELISA: Minimum Dilution: 1/1000;; Immunodiffusion: Minimum Dilution: 1/30; Maximum Dilution: 1/200
• Perservative Stabilisers: 0.09% Sodium Azide (NaN3)
• Immunogen: Native; Buffer Solution
• Antiserum Preparation: Antisera to human C-reactive protein were raised by repeated immunisations of goats with highly purified antigen. Purified IgG prepared by affinity chromatography.
• Target Species: Human
• Preparation and Storage: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.; Shelf Life: 18 months from date of despatch.

Testing Data #1

(Human C-Reactive Protein detected using Goat anti Human C-Reactive Protein (MBS223278))

Related Product Information for anti-CRP antibody

MBS223278 is specific for human C-reactive protein (CRP), a calcium-binding acute phase reactant belonging to the pentraxin family which is secreted into the plasma by the liver, in response to cytokine stimulation. In addition to binding to phosphocholine residues, CRP can bind to other autologous and extrinsic ligands on targets, including damaged cell membranes, ribonucleoprotein particles, apoptotic cells and constituents of micro-organisms, and may activate the classical complement pathway through C1q recognition, making CRP a factor in a variety of host defense mechanisms. Levels of plasma CRP are significantly increased during the acute phase response, tissue injury and infection and can be used as a marker of inflammation, disease progress and risk assessment of cardiovascular disease (CVD).

NCBI and Uniprot Product Information

• NCBI GI #: 55770842
• NCBI GeneID: 1401
• NCBI Accession #: NP_000558.2
• NCBI GenBank Nucleotide #: NM_000567.2
• UniProt Accession #: P02741; Q08AK3; Q8WW75; A8K078; D3DVD9; D3DVE0
• Molecular Weight: 10,415 Da
• NCBI Official Full Name: C-reactive protein
• NCBI Official Synonym Full Names: C-reactive protein, pentraxin-related
• NCBI Official Symbol: CRP
• NCBI Official Synonym Symbols: PTX1
• NCBI Protein Information: C-reactive protein; pentraxin 1
• UniProt Protein Name: C-reactive protein
• Protein Family: Cryparin
• UniProt Gene Name: CRP
• UniProt Synonym Gene Names: PTX1
• UniProt Entry Name: CRP_HUMAN

NCBI Description

The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]

Uniprot Description

CRP: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. Belongs to the pentaxin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1q23.2

Cellular Component: extracellular space; growth cone; extracellular region; filopodium

Molecular Function: choline binding; protein binding; protein homodimerization activity; low-density lipoprotein receptor binding; complement component C1q binding; cholesterol binding; low-density lipoprotein binding; virion binding; calcium ion binding

Biological Process: protein polymerization; defense response to Gram-positive bacterium; response to ethanol; negative regulation of vasodilation; wound healing; positive regulation of superoxide release; response to lead ion; acute-phase response; response to hypoxia; opsonization; inflammatory response; complement activation, classical pathway; aging