Chicken C-MYC Polyclonal Antibody | anti-MYC antibody

HRP Conjugated Chicken anti-C-MYC

Cat. Num. AAA560133

• Gene Names: MYC; MRTL; c-Myc; bHLHe39
• Purity: HRP A.P.
• Synonyms: C-MYC; Polyclonal Antibody; HRP Conjugated Chicken anti-C-MYC; HRP Conjugated Chicken anti C-MYC; anti-C-MYC; anti-MYC antibody

• Host: Chicken
• Clonality: Polyclonal
• Purity/Purification: HRP A.P.
• Form/Format: Liquid

• Application Notes: ELISA: 1.0 - 0.2 ug/ml Blotting: The anti C-MYC was an effective probe at 0.5 ug/mL.
• Buffer: 50 mM HEPES - Saline with Stabilizer
• Preservative: 0.002% Thimerosal
• Procedure: Chickens were immunized with EQKLISEEDL (C-MYC) conjugated with KLH. After multiple immunizations in Freunds adjuvant, eggs were collected. Antibodies were immunoaffinity purified using the peptide immobilized on a solid phase and conjugated with horseradish peroxidase.
• Preparation and Storage: Store at 4 degree C.; Shelf Life: 12 months from shipment date

Related Product Information for anti-MYC antibody

Chickens were immunized with C-MYC conjugated to a carrier protein. Eggs were collected and an IgY fraction was prepared. The resulting fraction was passed over an antigen containing immunoabsorbant from which the anti-C-MYC antibodies were immunoaffinity purified. Purification was followed by conjugation with horseradish peroxidase (HRP).

Product Categories/Family for anti-MYC antibody

Epitope tag

NCBI and Uniprot Product Information

• NCBI GI #: 396512
• NCBI GeneID: 4609
• UniProt Accession #: Q6LBK7; P01106; Q14899; Q14901; Q16591; Q7KZ54
• Molecular Weight: 7,012 Da
• NCBI Official Full Name: c-myc
• NCBI Official Synonym Full Names: v-myc myelocytomatosis viral oncogene homolog (avian)
• NCBI Official Symbol: MYC
• NCBI Official Synonym Symbols: MRTL; c-Myc; bHLHe39
• NCBI Protein Information: myc proto-oncogene protein; OTTHUMP00000158589; OTTHUMP00000227763; proto-oncogene c-Myc; transcription factor p64; class E basic helix-loop-helix protein 39; avian myelocytomatosis viral oncogene homolog; v-myc avian myelocytomatosis viral oncogene homolog; myc-related translation/localization regulatory factor
• UniProt Protein Name: C-myc protein
• Protein Family: C-Myc-binding protein
• UniProt Gene Name: c-myc
• UniProt Entry Name: Q6LBK7_HUMAN

NCBI Description

The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq]

Uniprot Description

Myc: a proto-oncogenic transcription factor that plays a role in cell proliferation, apoptosis and in the development of human tumors. Seems to activate the transcription of growth-related genes.

Protein type: Oncoprotein; Nucleolus; Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 8q24.21

Cellular Component: nucleoplasm; protein complex; nucleolus; nucleus; cytosol

Molecular Function: protein dimerization activity; protein binding; DNA binding; protein complex binding; transcription factor activity; transcription factor binding

Biological Process: cellular iron ion homeostasis; oxygen transport; positive regulation of transcription, DNA-dependent; positive regulation of caspase activity; Wnt receptor signaling pathway through beta-catenin; negative regulation of transcription from RNA polymerase II promoter; chromosome organization and biogenesis; positive regulation of fibroblast proliferation; transforming growth factor beta receptor signaling pathway; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; response to gamma radiation; cell cycle arrest; response to drug; transcription initiation from RNA polymerase II promoter; Notch signaling pathway; transcription, DNA-dependent; regulation of telomere maintenance; MAPKKK cascade; negative regulation of cell division; negative regulation of monocyte differentiation; negative regulation of stress-activated MAPK cascade; chromatin remodeling; ureteric bud branching; regulation of gene expression; negative regulation of fibroblast proliferation; energy reserve metabolic process; gene expression; positive regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus; positive regulation of epithelial cell proliferation; negative regulation of apoptosis

Disease: Burkitt Lymphoma