anti-Human, Mouse BTNL2 Polyclonal Antibody | anti-BTNL2 antibody

BTNL2

Cat. Num. AAA9125261

• Gene Names: BTNL2; SS2; BTN7; BTL-II; HSBLMHC1
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Affinity Purification
• Synonyms: BTNL2; Polyclonal Antibody; BTL-II; BTN7; HSBLMHC1; SS2; anti-BTNL2 antibody

• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Sequence Length: 455

• Applicable Applications for anti-BTNL2 antibody: Western Blot (WB)
• Application Notes: WB 1:500 - 1:200
• Source: Rabbit
• Immunogen: Recombinant funsion protein containing a sequence corresponding to amino acids 246-455 of human BTNL2 (NP_062548.1)
• Preparation and Storage: Store at -20°C. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using BTNL2 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 10s.)

Related Product Information for anti-BTNL2 antibody

This gene encodes a major histocompatibility complex, class II associated, type I transmembrane protein which belongs to the butyrophilin-like B7 family of immunoregulators. It is thought to be involved in immune surveillance, serving as a negative T-cell regulator by decreasing T-cell proliferation and cytokine release. The encoded protein contains an N-terminal signal peptide, two pairs of immunoglobulin-like domains, separated by a heptad peptide sequence, and a C-terminal transmembrane domain. Naturally occurring mutations in this gene are associated with sarcoidosis, rheumatoid arthritis, ulcerative colitis, inflammatory bowel disease, myositis, type 1 diabetes, systemic lupus erythematosus, acute coronary syndrome,and prostate cancer.

Product Categories/Family for anti-BTNL2 antibody

Polyclonal

NCBI and Uniprot Product Information

• NCBI GI #: 9624969
• NCBI GeneID: 56244
• NCBI Accession #: NP_062548.1
• NCBI GenBank Nucleotide #: NM_019602.1
• Molecular Weight: Calculated MW: 19kDa/27kDa/28kDa/30kDa/43kDa/50kDa; Observed MW: 60 kDa
• NCBI Official Full Name: butyrophilin-like protein 2
• NCBI Official Synonym Full Names: butyrophilin-like 2 (MHC class II associated)
• NCBI Official Symbol: BTNL2
• NCBI Official Synonym Symbols: SS2; BTN7; BTL-II; HSBLMHC1
• NCBI Protein Information: butyrophilin-like protein 2
• UniProt Protein Name: Butyrophilin-like protein 2
• Protein Family: Butyrophilin-like protein
• UniProt Gene Name: BTNL2
• UniProt Synonym Gene Names: BTL-II
• UniProt Entry Name: BTNL2_HUMAN

Uniprot Description

BTNL2: Negative regulator of T-cell proliferation. Genetic variation in BTNL2 is a cause of susceptibility to sarcoidosis type 2 (SS2). Sarcoidosis is an idiopathic, systemic, inflammatory disease characterized by the formation of immune granulomas in involved organs. Granulomas predominantly invade the lungs and the lymphatic system, but also skin, liver, spleen, eyes and other organs may be involved. A nucleotide transition affecting a splice donor site results in the use of an alternative splice site and the production of isoform 3. Individuals expressing isoform 3 have a higher risk for sarcoidosis. Belongs to the immunoglobulin superfamily. BTN/MOG family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: integral to membrane

Disease: Sarcoidosis, Susceptibility To, 2