Western Blot (WB)
(Western Blot analysis of BSND expression in transfected 293T cell line by BSND polyclonal antibody. Lane 1: BSND transfected lysate (35.2kD). Lane 2: Non-transfected lysate.)
Rabbit anti-Human BSND Polyclonal Antibody | anti-BSND antibody
BSND (Barttin, Bartter Syndrome, Infantile, with Sensorineural Deafness, BART, DFNB73, MGC119283, MGC119284, MGC119285)
Serum
Serum
Western Blot (WB)
(Western Blot analysis of BSND expression in transfected 293T cell line by BSND polyclonal antibody. Lane 1: BSND transfected lysate (35.2kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of BSND expression in transfected 293T cell line by BSND polyclonal antibody. Lane 1: BSND transfected lysate (35.2kD). Lane 2: Non-transfected lysate.)
Immunoprecipitation (IP)
(Immunoprecipitation of BSND transfected lysate using BSND rabbit polyclonal antibody and Protein A Magnetic Bead and immunoblotted with BSND mouse polyclonal antibody.)
Immunoprecipitation (IP)
(Immunoprecipitation of BSND transfected lysate using BSND rabbit polyclonal antibody and Protein A Magnetic Bead and immunoblotted with BSND mouse polyclonal antibody.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an essential beta subunit for CLC chloride channels. These heteromeric channels localize to basolateral membranes of renal tubules and of potassium-secreting epithelia of the inner ear. Mutations in this gene have been associated with Bartter syndrome with sensorineural deafness. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Functions as a beta-subunit for CLCNKA and CLCNKB chloride channels. In the kidney CLCNK/BSND heteromers mediate chloride reabsorption by facilitating its basolateral efflux. In the stria, CLCNK/BSND channels drive potassium secretion by recycling chloride for the basolateral SLC12A2 cotransporter. Ref.3 Ref.4
Subunit structure: Interacts with CLCNK channels. Forms heteromers with CLCNKA in the thin ascending limb of Henle and with CLCNKB in the thick ascending limb and more distal segments
By similarity. Ref.3 Ref.4
Subcellular location: Cell membrane; Multi-pass membrane protein
By similarity. Cytoplasm
By similarity. Note: A significant amount also observed intracellularly. Staining in membranes of the renal tubule and of potassium-secreting epithelia of the inner ear is basolateral
By similarity. Ref.3 Ref.4
Tissue specificity: Expressed primarily in kidney. Expressed in specific nephron segments and in the stria vascularis of the inner ear. Ref.1
Involvement in disease: Bartter syndrome 4A (BS4A) [MIM:602522]: An autosomal recessive disorder characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. Bartter syndrome type 4 is associated with sensorineural deafness.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.1 Ref.4 Ref.5 Ref.6
Sequence caution: The sequence BC069510 differs from that shown. Reason: Frameshift at several positions.
Research Articles on BSND
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Product Notes
The BSND bsnd (Catalog #AAA647346) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The BSND (Barttin, Bartter Syndrome, Infantile, with Sensorineural Deafness, BART, DFNB73, MGC119283, MGC119284, MGC119285) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's BSND can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP). Suitable for use in Immunoprecipitation and Western Blot. Researchers should empirically determine the suitability of the BSND bsnd for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MADEKTFRIG FIVLGLFLLA LGTFLMSHDR PQVYGTFYAM GSVMVIGGII WSMCQCYPKI TFVPADSDFQ GILSPKAMGL LENGLAAEMK SPSPQPPYVR LWEEAAYDQS LPDFSHIQMK VMSYSEDHRS LLAPEMGQPK LGTSDGGEGG PGDVQAWMEA AVVIHKGSDE SEGERRLTQS WPGPLACPQG PAPLASFQDD LDMDSSEGSS PNASPHDREE ACSPQQEPQG CRCPLDRFQD FALIDAPTLE DEPQEGQQWE IALPNNWQRY PRTKVEEKEA SDTGGEEPEK EEEDLYYGLP DGAGDLLPDK ELGFEPDTQG. It is sometimes possible for the material contained within the vial of "BSND, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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