Rabbit BRP44L Polyclonal Antibody | anti-BRP44L antibody

BRP44L (I51) Polyclonal Antibody?

Cat. Num. AAA3003405

• Gene Names: MPC1; MPYCD; BRP44L; CGI-129; SLC54A1
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: BRP44L; Polyclonal Antibody; BRP44L (I51) Polyclonal Antibody?; Mitochondrial pyruvate carrier 1; Brain protein 44-like protein; CGI-129; HSPC040; PNAS-115; MPC1; anti-BRP44L antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: BRP44L (I51) polyclonal antibody detects endogenous levels of BRP44L protein
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 109

• Applicable Applications for anti-BRP44L antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:200
• Immunogen: Synthetic peptide, corresponding to amino acids 20-70 of Human BRP44L.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry (IHC) analyzes of BRP44L (I51) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.)

Related Product Information for anti-BRP44L antibody

BRP44L (brain protein 44-like protein), also known as HSPC040 or CGI-129, is a 109 amino acid mitochondrial protein belonging to the UPF0041 family. The gene that encodes BRP44L maps to human chromosome 6. Making up nearly 6% of the human genome, chromosome 6 contains around 1, 200 genes within 170 million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. Porphyria cutanea tarda is associated with chromosome 6 through the HFE gene which, when mutated, predisposes an individual to developing this porphyria. Notably, the PARK2 gene, which is associated with Parkinson's disease, and the genes encoding the major histocompatiblity complex proteins, which are key molecular components of the immune system and determine predisposition to rheumatic diseases, are also located on chromosome 6. Stickler syndrome, 21-hydroxylase deficiency and maple syrup urine disease are also associated with genes on chromosome 6. A bipolar disorder susceptibility locus has been identified on the q arm of chromosome 6.

NCBI and Uniprot Product Information

• NCBI GI #: 7706369
• NCBI GeneID: 51660
• NCBI Accession #: NP_057182.1
• NCBI GenBank Nucleotide #: NP_057182.1
• UniProt Accession #: Q9Y5U8
• Molecular Weight: ~ 12kDa
• NCBI Official Full Name: mitochondrial pyruvate carrier 1 isoform 1
• NCBI Official Synonym Full Names: mitochondrial pyruvate carrier 1
• NCBI Official Symbol: MPC1
• NCBI Official Synonym Symbols: MPYCD; BRP44L; CGI-129; SLC54A1
• NCBI Protein Information: mitochondrial pyruvate carrier 1
• UniProt Protein Name: Mitochondrial pyruvate carrier 1
• UniProt Gene Name: MPC1
• UniProt Synonym Gene Names: BRP44L
• UniProt Entry Name: MPC1_HUMAN

NCBI Description

The protein encoded by this gene is part of an MPC1/MPC2 heterodimer that is responsible for transporting pyruvate into mitochondria. The encoded protein is found in the inner mitochondrial membrane. Defects in this gene are a cause of mitochondrial pyruvate carrier deficiency. Several transcript variants, some protein coding and one non-protein coding, have been found for this gene. [provided by RefSeq, Aug 2012]

Uniprot Description

BRP44L: Mediates the uptake of pyruvate into mitochondria. Defects in MPC1 are the cause of mitochondrial pyruvate carrier deficiency (MPYCD). An autosomal recessive metabolic disorder characterized by severely delayed psychomotor development, mild dysmorphic features, hepatomegaly, marked metabolic acidosis, hyperlactacidemia with normal lactate/pyruvate, and encephalopathy. Some patients have epilepsy and peripheral neuropathy. Belongs to the mitochondrial pyruvate carrier (MPC) family.

Protein type: Membrane protein, multi-pass; Mitochondrial

Chromosomal Location of Human Ortholog: 6q27

Cellular Component: mitochondrion; mitochondrial inner membrane; integral to membrane

Molecular Function: pyruvate transmembrane transporter activity

Biological Process: cellular metabolic process; mitochondrial pyruvate transport; pyruvate metabolic process

Disease: Mitochondrial Pyruvate Carrier Deficiency