Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded MBS7045112 using human lung cancer at dilution 1:100)
Rabbit anti-Human BRD7 Polyclonal Antibody | anti-BRD7 antibody
BRD7 Antibody
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded MBS7045112 using human lung cancer at dilution 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded MBS7045112 using human lung cancer at dilution 1:100)
Immunofluorescence (IF)
(Immunofluorescent analysis of MCF7 cells using MBS7045112 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))
Immunofluorescence (IF)
(Immunofluorescent analysis of MCF7 cells using MBS7045112 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Uniprot Description
BRD7: a bromodomain protein that binds dishevelled-1 (DVL1) and enhances Wnt signaling by inhibiting GSK3B. Interacts with DVL1, PTPN13, IRF2 and HNRPUL1. Associates with histones and E1B-AP5. Binds acetylated histone peptides, most notably H3 peptide acetylated at Lys14. Associates with histones and E1B-AP5. Its bromodomain is found in many chromatin-associated proteins and most known histone acetyltransferases. Inhibits G1-S progression by transcriptional regulation of molecules in the ras and Rb pathways. Plays an important role in transcriptional activation and chromatin remodeling. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription regulation; Histone-binding; Tumor suppressor; Cell cycle regulation
Chromosomal Location of Human Ortholog: 16q12
Cellular Component: cytoplasm; nucleoplasm; nucleus
Molecular Function: histone binding; p53 binding; protein binding; transcription coactivator activity; transcription corepressor activity; transcription factor binding
Biological Process: negative regulation of cell proliferation; negative regulation of transcription, DNA-dependent; positive regulation of histone acetylation; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter
Research Articles on BRD7
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Product Notes
The BRD7 brd7 (Catalog #AAA7045112) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The BRD7 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's BRD7 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF). Researchers should empirically determine the suitability of the BRD7 brd7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BRD7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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