Western Blot (WB)
(Western blot analysis of Bora in mouse brain tissue lysate with Bora antibody at (A) 1 and (B) 2 ug/mL.)
Rabbit Bora Polyclonal Antibody | anti-Bora antibody
Bora Antibody
Gene Names
BORA; C13orf34
Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot, Immunohistochemistry
Purity
Affinity chromatography purified via peptide column
Synonyms
Bora; Polyclonal Antibody; Bora Antibody; Protein aurora borealis; C13orf34; Chromosome 13 open reading frame 34; anti-Bora antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
634
Applicable Applications for anti-Bora antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Immunogen Type
Peptide
Immunogen Description
Raised against a 15 amino acid peptide from near the carboxy terminus of human Bora.
Target Name
Bora
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Western Blot (WB)
(Western blot analysis of Bora in mouse brain tissue lysate with Bora antibody at (A) 1 and (B) 2 ug/mL.)
Western Blot (WB)
(Western blot analysis of Bora in mouse brain tissue lysate with Bora antibody at (A) 1 and (B) 2 ug/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of Bora in mouse brain tissue with Bora antibody at 2.5 ug/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of Bora in mouse brain tissue with Bora antibody at 2.5 ug/mL.)
Related Product Information for anti-Bora antibody
Bora (Protein aurora borealis) is a key activator of Aurora Related Protein Kinase A (ARK-1), which is a centrosome-associated serine/threonine kinase that regulates centrosome maturation, bipolar spindle assembly and chromosome segregation during mitosis. Bora is localized to the nucleus until mitosis is initiated, then translocates to the cytoplasm in a Cdc2 dependent manner. Activation of Cdc2 initiates the release of Bora into the cytoplasm where it can bind and activate ARK-1. PLK1 (polo-like kinase-1) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation by ARK-1. Bora and ARK-1 cooperatively activate PLK1 and control mitotic entry. Bora mutants result in multipolar spindles in mitosis identical to those observed when ARK-1 function is blocked. Thus, the ARK1-Bora-PLK1 regulatory circuit in mammalian cells elucidates a key mechanism in cell cycle regulation. At least three isoforms of Bora are known to exist.
Product Categories/Family for anti-Bora antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
53,438 Da
NCBI Official Full Name
protein aurora borealis isoform 2
NCBI Official Synonym Full Names
bora, aurora kinase A activator
NCBI Official Symbol
BORA
NCBI Official Synonym Symbols
C13orf34
NCBI Protein Information
protein aurora borealis
UniProt Protein Name
Protein aurora borealis
Protein Family
UniProt Gene Name
BORA
UniProt Synonym Gene Names
C13orf34; HsBora
UniProt Entry Name
BORA_HUMAN
NCBI Description
BORA is an activator of the protein kinase Aurora A (AURKA; MIM 603072), which is required for centrosome maturation, spindle assembly, and asymmetric protein localization during mitosis (Hutterer et al., 2006 [PubMed 16890155]).[supplied by OMIM, Mar 2008]
Uniprot Description
BORA: Required for the activation of AURKA at the onset of mitosis. Interacts with AURKA. Belongs to the BORA family.
Protein type: Activator
Chromosomal Location of Human Ortholog: 13q22.1
Cellular Component: cytosol
Molecular Function: protein binding; protein kinase binding
Biological Process: mitosis; regulation of protein localization; cell division; regulation of mitosis; mitotic cell cycle; G2/M transition of mitotic cell cycle
Research Articles on Bora
Similar Products
Product Notes
The Bora bora (Catalog #AAA9412697) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Bora Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Bora can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the Bora bora for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Bora, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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