Rabbit anti-Human, Mouse BMPR1B Polyclonal Antibody | anti-BMPR1B antibody

BMPR1B, NT (K15) (Bone Morphogenetic Protein Receptor Type-1B, BMP Type-1B Receptor, BMPR-1B, CDw293) (Biotin)

Cat. Num. AAA6465700

• Gene Names: BMPR1B; ALK6; ALK-6; CDw293
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot
• Purity: Purified by Protein G Affinity Chromatography
• Synonyms: BMPR1B; Polyclonal Antibody; NT (K15) (Bone Morphogenetic Protein Receptor Type-1B; BMP Type-1B Receptor; BMPR-1B; CDw293) (Biotin); anti-BMPR1B antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human BMPR1B. Species Crossreactivity: mouse
• Purity/Purification: Purified by Protein G Affinity Chromatography
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-BMPR1B antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 1-30 in the N-terminal region of human BMPR1B, UniProt Accession #O00238.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of MBS625533 in NCI-H460 cell lysate. BMPR1B (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.)

Product Categories/Family for anti-BMPR1B antibody

Antibodies; Receptors; Growth Factor

References

1. Lehmann, K., et al., Proc. Natl. Acad. Sci. USA 100(21):12277-12282 (2003). 2. Astrom, A.K., et al., Mamm. Genome 10(3):299-302 (1999). 3. Ide, H., et al., Oncogene 14(11):1377-1382 (1997). 4. ten Dijke, P., et al., Science 264(5155):101-104 (1994). 5. Ide, H., et al., Cytogenet. Cell Genet. 81(3-4), 285-286 (1998).

NCBI and Uniprot Product Information

• NCBI GI #: 4502431
• NCBI GeneID: 658
• NCBI Accession #: NP_001194
• NCBI GenBank Nucleotide #: NM_001203.2
• UniProt Accession #: O00238; P78366; B2R953; B4DSV1
• NCBI Official Full Name: bone morphogenetic protein receptor type-1B isoform b
• NCBI Official Synonym Full Names: bone morphogenetic protein receptor, type IB
• NCBI Official Symbol: BMPR1B
• NCBI Official Synonym Symbols: ALK6; ALK-6; CDw293
• NCBI Protein Information: bone morphogenetic protein receptor type-1B; BMPR-1B; BMP type-1B receptor; activin receptor-like kinase 6; serine/threonine receptor kinase
• UniProt Protein Name: Bone morphogenetic protein receptor type-1B
• Protein Family: Bone morphogenetic protein receptor
• UniProt Gene Name: BMPR1B
• UniProt Synonym Gene Names: BMP type-1B receptor; BMPR-1B
• UniProt Entry Name: BMR1B_HUMAN

NCBI Description

This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Uniprot Description

BMPR1B: a kinase of the STKR family. A type I cell-surface receptor for bone morphogenetic protein. Expressed at ighest level in the prostate. May be upregulated by androgen stimulation in cells which expresses the androgen receptor.

Protein type: Protein kinase, Ser/Thr (receptor); Kinase, protein; EC 2.7.11.30; Membrane protein, integral; Protein kinase, TKL; TKL group; STKR family; Type1 subfamily

Chromosomal Location of Human Ortholog: 4q22-q24

Cellular Component: integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: protein serine/threonine kinase activity; protein binding; transforming growth factor beta receptor activity, type I; metal ion binding; SMAD binding; ATP binding; transmembrane receptor protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: chondrocyte development; positive regulation of bone mineralization; protein amino acid phosphorylation; limb morphogenesis; BMP signaling pathway; positive regulation of osteoblast differentiation; ovulation cycle; dorsal/ventral pattern formation; eye development; retina development in camera-type eye; proteoglycan biosynthetic process; ovarian cumulus expansion; inflammatory response; positive regulation of cell differentiation; skeletal development; cartilage condensation; retinal ganglion cell axon guidance

Disease: Brachydactyly, Type A2; Chondrodysplasia, Acromesomelic, With Genital Anomalies