Rabbit anti-Human BMP7 BMP7 Polyclonal Antibody | anti-BMP7 antibody

BMP7 antibody

Cat. Num. AAA535915

• Gene Names: Bmp7; BMP-7
• Reactivity: Human BMP7
• Applications: ELISA, Western Blot
• Synonyms: BMP7; Polyclonal Antibody; BMP7 antibody; Polyclonal BMP7; Anti-BMP7; BMP-7; 7; Bone Morphogenetic; OP-1; BMP 7; anti-BMP7 antibody

• Host: Rabbit
• Reactivity: Human BMP7
• Clonality: Polyclonal
• Specificity: Human BMP7
• Form/Format: Lyophilized from PBS, pH 7.2.
• Sequence Length: 141

• Applicable Applications for anti-BMP7 antibody: ELISA (EIA), Inhibition, Western Blot (WB)
• Application Notes: ELISA: 0.5-2 ug/ml; Inhibition: 0.4-0.6 ug/ml; WB: 0.1-0.2 ug/ml
• Biological Significance: TGF beta family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. BMP-7, also known as osteogenic protein-1 or OP-1, is a potent bone inducing agent, which in the presence of appropriate osteoconductive carrier (e.g. collagen sponge or synthetic hydroxyapatite) can be used in the treatment of bone defects.
• Immunogen: BMP7 antibody was raised in rabbit using highly pure recombinant human BMP-7 as the immunogen.
• Preparation and Storage: Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.

Related Product Information for anti-BMP7 antibody

Affinity purified Rabbit polyclonal BMP7 antibody

Product Categories/Family for anti-BMP7 antibody

Differentiation & Development; Purified Polyclonal Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 3337108
• NCBI GeneID: 85272
• NCBI Accession #: BAA31853
• NCBI GenBank Nucleotide #: NM_001719.2
• UniProt Accession #: P18075; Q9H512; Q9NTQ7
• Molecular Weight: 28.8 kDa (predicted detection band MW)
• NCBI Official Full Name: bone moorphogenic protein-7, partial
• NCBI Official Synonym Full Names: bone morphogenetic protein 7
• NCBI Official Symbol: Bmp7
• NCBI Official Synonym Symbols: BMP-7
• NCBI Protein Information: bone morphogenetic protein 7
• UniProt Protein Name: Bone morphogenetic protein 7
• Protein Family: Bone morphogenetic protein
• UniProt Gene Name: BMP7
• UniProt Synonym Gene Names: OP1; BMP-7; OP-1
• UniProt Entry Name: BMP7_HUMAN

NCBI Description

binds to cell surface heparan sulfate [RGD, Feb 2006]

Uniprot Description

BMP7: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1. Expressed in the kidney and bladder. Lower levels seen in the brain. Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 20q13

Cellular Component: extracellular matrix; extracellular space; extracellular region

Molecular Function: heparin binding; protein binding; growth factor activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: axon guidance; negative regulation of MAP kinase activity; response to peptide hormone stimulus; extracellular matrix organization and biogenesis; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; negative regulation of NF-kappaB import into nucleus; embryonic pattern specification; response to estradiol stimulus; negative regulation of cell cycle; BMP signaling pathway; regulation of apoptosis; response to vitamin D; epithelial cell differentiation; ureteric bud development; dendrite development; mesonephros development; skeletal development; embryonic limb morphogenesis; ossification; positive regulation of heterotypic cell-cell adhesion; positive regulation of bone mineralization; odontogenesis of dentine-containing teeth; positive regulation of osteoblast differentiation; negative regulation of neuron differentiation; mesenchymal cell differentiation; mesoderm formation; branching morphogenesis of a tube; inhibition of NF-kappaB transcription factor; cartilage development; negative regulation of mitosis; negative regulation of Notch signaling pathway; epithelial to mesenchymal transition; negative regulation of phosphorylation; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; embryonic camera-type eye morphogenesis; negative regulation of transcription, DNA-dependent; metanephros development; neurite morphogenesis; growth