Rabbit BMP2K Polyclonal Antibody | anti-BMP2K antibody

BMP2K Polyclonal Antibody

Cat. Num. AAA3006350

• Gene Names: BMP2K; BIKE; HRIHFB2017
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: BMP2K; Polyclonal Antibody; BMP2K Polyclonal Antibody; BMP-2-inducible protein kinase; BIKe; BIKE; HRIHFB2017; anti-BMP2K antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: BMP2K polyclonal antibody detects endogenous levels of BMP2K protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 662

• Applicable Applications for anti-BMP2K antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human BMP2K.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of BMP2K polyclonal antibody at 1:500 dilutionLane1:A549 whole cell lysateLane2:NIH-3T3 whole cell lysateLane3:PC12 whole cell lysate)

Related Product Information for anti-BMP2K antibody

The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. BMP2K (BMP2 inducible kinase), also known as BIKE, is a 1, 161 amino acid nuclear protein that contains one protein kinase domain and belongs to the Ser/Thr protein kinase family. Thought to be involved in osteoblast differentiation, BMP2K catalyzes the ATP-dependent phosphorylation of bone morphogenic proteins (BMPs); proteins that are essential for proper cartilage and bone formation. Via its catalytic activity, BMP2K may play a role in signaling pathways that mediate bone growth and cellular differentiation. Three isoforms of BMP2K exist due to alternative splicing events.

NCBI and Uniprot Product Information

• NCBI GI #: 38787904
• NCBI GeneID: 55589
• NCBI Accession #: NP_060063.2
• NCBI GenBank Nucleotide #: NP_060063.2
• UniProt Accession #: Q9NSY1
• Molecular Weight: ~ 129kDa
• NCBI Official Full Name: BMP-2-inducible protein kinase isoform b
• NCBI Official Synonym Full Names: BMP2 inducible kinase
• NCBI Official Symbol: BMP2K
• NCBI Official Synonym Symbols: BIKE; HRIHFB2017
• NCBI Protein Information: BMP-2-inducible protein kinase
• UniProt Protein Name: BMP-2-inducible protein kinase
• Protein Family: BMP-2-inducible protein kinase
• UniProt Gene Name: BMP2K
• UniProt Synonym Gene Names: BIKE; BIKe
• UniProt Entry Name: BMP2K_HUMAN

NCBI Description

This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

BIKE: May be involved in osteoblast differentiation. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Other group; NAK family

Chromosomal Location of Human Ortholog: 4q21.21

Cellular Component: nucleoplasm

Molecular Function: protein serine/threonine kinase activity; phosphatase regulator activity; ATP binding

Biological Process: regulation of catalytic activity; regulation of bone mineralization; protein amino acid phosphorylation