Rabbit anti-Human, Mouse BMP11 Polyclonal Antibody | anti-BMP11 antibody

BMP11, NT (Growth/Differentiation Factor 11, GDF-11, Bone Morphogenetic Protein 11, BMP-11, GDF11) (MaxLight 750)

Cat. Num. AAA6465614

• Gene Names: GDF11; BMP11; BMP-11
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by Protein A/G Affinity Chromatography.
• Synonyms: BMP11; Polyclonal Antibody; NT (Growth/Differentiation Factor 11; GDF-11; Bone Morphogenetic Protein 11; BMP-11; GDF11) (MaxLight 750); anti-BMP11 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human BMP11. Species crossreactivity: mouse
• Purity/Purification: Purified by Protein A/G Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.

• Applicable Applications for anti-BMP11 antibody: Immunohistochemistry (IHC) Paraffin, FLISA, Western Blot (WB)
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 32-61 in the N-terminal region of human BMP11, UniProt Accession #O95390.
• Conjugate: MaxLight750
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of 293 cell lysates (2ug/lane) usingMBS630873. in either nontransfected (Lane 1) or transiently transfected with the BMP11 gene (Lane 2) (Origene Technologies) BMP11 (arrow).)

Immunohistochemistry (IHC)

(Formalin-fixed and paraffin-embedded human colon carcinoma tissue usingMBS630873, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.)

Immunohistochemistry (IHC)

(Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted withMBS630873, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.)

Product Categories/Family for anti-BMP11 antibody

Antibodies; Growth Factors; Cytokines

References

1. Lee, S.J., et al., Curr. Opin. Genet. Dev. 9(5): 604-607 (1999). 2. McPherron, A.C., et al., Nat. Genet. 22(3): 260-264 (1999). 3. Gamer, L.W., et al., Dev. Biol. 208(1): 222-232 (1999). 4. Hillier, L.D., et al., Genome Res. 6(9): 807-828 (1996).

NCBI and Uniprot Product Information

• NCBI GI #: 5031613
• NCBI GeneID: 10220
• NCBI Accession #: NP_005802
• NCBI GenBank Nucleotide #: NM_005811.4
• UniProt Accession #: O95390; Q9UID1; Q9UID2
• Molecular Weight: 14.8kDa (132aa)
• NCBI Official Full Name: growth/differentiation factor 11 preproprotein
• NCBI Official Synonym Full Names: growth differentiation factor 11
• NCBI Official Symbol: GDF11
• NCBI Official Synonym Symbols: BMP11; BMP-11
• NCBI Protein Information: growth/differentiation factor 11
• UniProt Protein Name: Growth/differentiation factor 11
• UniProt Gene Name: GDF11
• UniProt Synonym Gene Names: BMP11; GDF-11; BMP-11
• UniProt Entry Name: GDF11_HUMAN

NCBI Description

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role in the development of the nervous and other organ systems, and may regulate aging. [provided by RefSeq, Aug 2016]

Uniprot Description

GDF11: Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern. Belongs to the TGF-beta family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 12q13.2

Cellular Component: extracellular space

Molecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: nervous system development; cell maturation; palate development; regulation of apoptosis; negative regulation of cell proliferation; negative regulation of cell differentiation; camera-type eye morphogenesis; spinal cord anterior/posterior patterning; ureteric bud development; regulation of MAPKKK cascade; pancreas development; mesoderm development; metanephros development; skeletal development; cell development; growth