Rabbit BMP1 Polyclonal Antibody | anti-BMP1 antibody
BMP1 Antibody FITC-Conjugated
ELISA: 1:2,000
Immunoprecipitation: 1:200
Western Blot: 1:500
Cleaves the C-terminal propeptides of procollagen I, II and II. Induces bone and cartilage formation.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, this gene encodes a protein that is not closely related to other known growth factors. This gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region. [provided by RefSeq, Aug 2008]
Uniprot Description
BMP1: Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Defects in BMP1 are a cause of autosomal recessive osteogenesis imperfecta (AR-OI). A connective tissue disorder characterized by bone fragility, progressively deforming bones, bowing of limbs due to multiple fractures, very short stature, a triangular face, severe scoliosis, and grayish sclera. AR-OI due to BMP1 mutations belongs to the group of osteogenesis imperfecta type III in the Sillence classification. Belongs to the peptidase M12A family. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytokine; Protease; EC 3.4.24.19
Chromosomal Location of Human Ortholog: 8p21.3
Cellular Component: extracellular region; extracellular space; Golgi apparatus; proteinaceous extracellular matrix
Molecular Function: calcium ion binding; cytokine activity; growth factor activity; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; protein binding; serine-type endopeptidase activity; transforming growth factor beta receptor binding; zinc ion binding
Biological Process: BMP signaling pathway; cartilage condensation; cell development; extracellular matrix disassembly; lipoprotein metabolic process; multicellular organismal development; ossification; proteolysis; regulation of apoptosis; regulation of MAPKKK cascade; skeletal development
Disease: Osteogenesis Imperfecta, Type Xiii
Research Articles on BMP1
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Product Notes
The BMP1 bmp1 (Catalog #AAA541070) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The BMP1 Antibody FITC-Conjugated reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's BMP1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB). Dot Blot: 1:2,000 ELISA: 1:2,000 Immunoprecipitation: 1:200 Western Blot: 1:500. Researchers should empirically determine the suitability of the BMP1 bmp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BMP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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