Rabbit anti-Human BHMT2 Polyclonal Antibody | anti-BHMT2 antibody

BHMT2 Rabbit pAb

Cat. Num. AAA4758149

• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity purified
• Synonyms: BHMT2; Polyclonal Antibody; BHMT2 Rabbit pAb; anti-BHMT2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Purity/Purification: Affinity purified
• Form/Format: -20 degree C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

• Applicable Applications for anti-BHMT2 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Fusion protein of human BHMT2
• Conjugation: Unconjugated
• Molecular Function: Homocysteine is a sulfur-containing amino acid that plays a crucial role in methylation reactions. Transfer of the methyl group from betaine to homocysteine creates methionine, which donates the methyl group to methylate DNA, proteins, lipids, and other intracellular metabolites. The protein encoded by this gene is one of two methyl transferases that can catalyze the transfer of the methyl group from betaine to homocysteine. Anomalies in homocysteine metabolism have been implicated in disorders ranging from vascular disease to neural tube birth defects such as spina bifida. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Modification: Unmodified
• Preparation and Storage: Store at 4 degree C for short term. Store at -20 degree C for long term. Avoid freeze/thaw cycle.

Western Blot (WB)

(Gel: 8%SDS-PAGE, Lysate: 40 ug, Lane: Human kidney tissue lysate, Primary antibody: 824257(BHMT2 Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 second)

Immunohistochemistry (IHC)

(The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using 824257(BHMT2 Antibody) at dilution 1/45. (Original magnification: ×200))

Immunohistochemistry (IHC)

(The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using 824257(BHMT2 Antibody) at dilution 1/45. (Original magnification: ×200))

Product Categories/Family for anti-BHMT2 antibody

Primary antibody

NCBI and Uniprot Product Information

• NCBI GI #: 18088852
• NCBI GeneID: 23743
• UniProt Accession #: Q9H2M3; Q9NXX7; B7Z516
• Molecular Weight: 33,167 Da
• NCBI Official Full Name: Homo sapiens betaine-homocysteine methyltransferase 2, mRNA
• NCBI Official Synonym Full Names: betaine--homocysteine S-methyltransferase 2
• NCBI Official Symbol: BHMT2
• NCBI Protein Information: S-methylmethionine--homocysteine S-methyltransferase BHMT2
• UniProt Protein Name: S-methylmethionine--homocysteine S-methyltransferase BHMT2
• Protein Family: S-methylmethionine--homocysteine S-methyltransferase
• UniProt Gene Name: BHMT2
• UniProt Synonym Gene Names: SMM-hcy methyltransferase

NCBI Description

Homocysteine is a sulfur-containing amino acid that plays a crucial role in methylation reactions. Transfer of the methyl group from betaine to homocysteine creates methionine, which donates the methyl group to methylate DNA, proteins, lipids, and other intracellular metabolites. The protein encoded by this gene is one of two methyl transferases that can catalyze the transfer of the methyl group from betaine to homocysteine. Anomalies in homocysteine metabolism have been implicated in disorders ranging from vascular disease to neural tube birth defects such as spina bifida. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]

Uniprot Description

Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor.