Rabbit beta-Catenin Polyclonal Antibody | anti-CTNNB1 antibody
CTNNB1 Polyclonal Antibody
Gene Names
CTNNB1; CTNNB; MRD19; armadillo
Reactivity
Human, mouse, rat
Applications
Western Blot, Immunohistochemistry, Immunocytochemistry, Immunoprecipitation
Purity
Affinity purification
Synonyms
beta-Catenin; Polyclonal Antibody; CTNNB1 Polyclonal Antibody; CTNNB1; beta-Catenin ; b-Catenin ; CTNNB1 ; CTNNB ; DKFZp686D02253 ; FLJ25606 ; FLJ37923 ; Catenin beta-1 ; Beta-catenin ; beta-Catenin;; anti-CTNNB1 antibody
Host
Rabbit
Reactivity
Human, mouse, rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Affinity purification
Sequence Length
781
Applicable Applications for anti-CTNNB1 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
Application Notes
Western Blot (WB): 1:500-1: 2000
Immunohistochemistry (IHC): 1:501: 200
Immunocytochemistry (ICC): 1:50-1: 200
Immunoprecipitation (IP): 1:20-1: 50
Immunohistochemistry (IHC): 1:501: 200
Immunocytochemistry (ICC): 1:50-1: 200
Immunoprecipitation (IP): 1:20-1: 50
Immunogen
A synthetic -peptide of human CTNNB1
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at -20 degree C or -80 degree C. Avoid freeze / thaw cycles
Related Product Information for anti-CTNNB1 antibody
beta-catenin is a key downstream effector in the Wnt signaling pathway (1). It is implicated in two major biological processes in vertebrates: early embryonic development (2) and tumorigenesis (3). CK1 phosphorylates beta-catenin at Ser45. This phosphorylation event primes beta-catenin for subsequent phosphorylation by GSK-3 (4-6). GSK-3beta destabilizes beta-catenin by phosphorylating it at Ser33, Ser37, and Thr41 (7). Mutations at these sites result in the stabilization of beta-catenin protein levels and have been found in many tumor cell lines (8).
References
1. Cadigan, K.M. and Nusse, R. (1997) Genes Dev. 11, 3286-3305. 2. Wodarz, A. and Nusse, R. (1998) Annu. Rev. Cell. Dev. Biol. 14, 59-88. 3. Polakis, P. (1999) Curr. Opin. Genet. Dev. 9, 15-21. 4. Amit, S. et al. (2002) Genes Dev. 16, 1066-1076. 5. Lin, C. et al. (2002) Cell 108, 837-847. 6. Yanagawa, S. et al. (2002) EMBO J. 21, 1733-1742. 7. Yost, C. et al. (1996) Genes Dev. 10, 1443-1454. 8. Morin, P.J. (1997) Science 275, 1787-1790.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
92kDa
NCBI Official Full Name
catenin beta-1
NCBI Official Synonym Full Names
catenin (cadherin-associated protein), beta 1, 88kDa
NCBI Official Symbol
CTNNB1
NCBI Official Synonym Symbols
CTNNB; MRD19; armadillo
NCBI Protein Information
catenin beta-1
UniProt Protein Name
Catenin beta-1
Protein Family
UniProt Gene Name
CTNNB1
UniProt Synonym Gene Names
CTNNB
UniProt Entry Name
CTNB1_HUMAN
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Product Notes
The CTNNB1 ctnnb1 (Catalog #AAA125950) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CTNNB1 Polyclonal Antibody reacts with Human, mouse, rat and may cross-react with other species as described in the data sheet. AAA Biotech's beta-Catenin can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP). Western Blot (WB): 1:500-1: 2000 Immunohistochemistry (IHC): 1:501: 200 Immunocytochemistry (ICC): 1:50-1: 200 Immunoprecipitation (IP): 1:20-1: 50. Researchers should empirically determine the suitability of the CTNNB1 ctnnb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "beta-Catenin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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