Western Blot (WB)
(BEST3 Antibody (N-term) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the BEST3 antibody detected the BEST3 protein (arrow).)
Rabbit anti-Human BEST3 Polyclonal Antibody | anti-BEST3 antibody
BEST3 Antibody (N-term)
Western Blot (WB)
(BEST3 Antibody (N-term) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the BEST3 antibody detected the BEST3 protein (arrow).)
Western Blot (WB)
(BEST3 Antibody (N-term) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the BEST3 antibody detected the BEST3 protein (arrow).)
which includes BEST1 (MIM 607854), the gene mutant in vitelliform
macular dystrophy (VMD; MIM 153700), and 2 other BEST1-like genes,
BEST2 (MIM 607335) and BEST4 (MIM 607336). Bestrophins are
transmembrane (TM) proteins that share a homology region containing
a high content of aromatic residues, including an invariant
arg-phe-pro (RFP) motif. The bestrophin genes share a conserved
gene structure, with almost identical sizes of the 8 RFP-TM
domain-encoding exons and highly conserved exon-intron boundaries.
Each of the 4 bestrophin genes has a unique 3-prime end of variable
length (Stohr et al., 2002 [PubMed 12032738]; Tsunenari et al.,
2003 [PubMed 12907679]).
Qu, Z.Q., et al. J. Biol. Chem. 282(24):17460-17467(2007)
Tsunenari, T., et al. J. Biol. Chem. 278(42):41114-41125(2003)
Stohr, H., et al. Eur. J. Hum. Genet. 10(4):281-284(2002)
Marquardt, A., et al. Hum. Mol. Genet. 7(9):1517-1525(1998)
NCBI and Uniprot Product Information
NCBI Description
BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in vitelliform macular dystrophy (VMD; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM 607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002 [PubMed 12032738]; Tsunenari et al., 2003 [PubMed 12907679]).[supplied by OMIM, Mar 2008]
Uniprot Description
VMD2L3: Forms calcium-sensitive chloride channels. Permeable to bicarbonate. Belongs to the bestrophin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter, ion channel
Chromosomal Location of Human Ortholog: 12q15
Cellular Component: plasma membrane
Molecular Function: chloride channel activity
Biological Process: negative regulation of ion transport
Research Articles on BEST3
Similar Products
Product Notes
The BEST3 best3 (Catalog #AAA9213209) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 40-68. The BEST3 Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's BEST3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the BEST3 best3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BEST3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
