Immunohistochemistry (IHC)
(Anti-Beclin 1 Picoband antibody, MBS177035-1.JPGIHC(P): Mouse Intestine Tissue )
Rabbit Beclin 1 Polyclonal Antibody | anti-BECN1 antibody
Anti-Beclin 1 Antibody
Immunohistochemistry (IHC)
(Anti-Beclin 1 Picoband antibody, MBS177035-1.JPGIHC(P): Mouse Intestine Tissue )
Immunohistochemistry (IHC)
(Anti-Beclin 1 Picoband antibody, MBS177035-1.JPGIHC(P): Mouse Intestine Tissue )
Immunohistochemistry (IHC)
(Anti-Beclin 1 Picoband antibody, MBS177035-2.JPGIHC(P): Mouse Spleen Tissue )
Immunohistochemistry (IHC)
(Anti-Beclin 1 Picoband antibody, MBS177035-2.JPGIHC(P): Mouse Spleen Tissue )
Immunohistochemistry (IHC)
(Anti-Beclin 1 Picoband antibody, MBS177035-3.JPGIHC(P): Rat Intestine Tissue )
Immunohistochemistry (IHC)
(Anti-Beclin 1 Picoband antibody, MBS177035-3.JPGIHC(P): Rat Intestine Tissue )
Immunohistochemistry (IHC)
(Anti-Beclin 1 Picoband antibody, MBS177035-4.JPGIHC(P): Rat Spleen Tissue )
Immunohistochemistry (IHC)
(Anti-Beclin 1 Picoband antibody, MBS177035-4.JPGIHC(P): Rat Spleen Tissue )
Testing Data
(Anti-Beclin 1 Picoband antibody, MBS177035-5.jpgAll lanes: Anti-Beclin-1 (MBS177035) at 0.5ug/mlLane 1: Colo320 Whole Cell Lysate at 40ugLane 2: HepG2 Whole Cell Lysate at 40ugLane 3: PANC Whole Cell Lysate at 40ugLane 4: A431 Whole Cell Lysate at 40ugLane 5: Smmc Whole Cell Lysate at 40ugLane 6: Jurkat Whole Cell Lysate at 40ugLane 7: SW620 Whole Cell Lysate at 40ugLane 8: U87 Whole Cell Lysate at 40ugPredicted bind size: 52KDObserved bind size: 60KD)
Testing Data
(Anti-Beclin 1 Picoband antibody, MBS177035-5.jpgAll lanes: Anti-Beclin-1 (MBS177035) at 0.5ug/mlLane 1: Colo320 Whole Cell Lysate at 40ugLane 2: HepG2 Whole Cell Lysate at 40ugLane 3: PANC Whole Cell Lysate at 40ugLane 4: A431 Whole Cell Lysate at 40ugLane 5: Smmc Whole Cell Lysate at 40ugLane 6: Jurkat Whole Cell Lysate at 40ugLane 7: SW620 Whole Cell Lysate at 40ugLane 8: U87 Whole Cell Lysate at 40ugPredicted bind size: 52KDObserved bind size: 60KD)
Background: Beclin-1, also known as also known as ATG6 or VPS30 is a protein that in humans is encoded by the BECN1 gene. Beclin-1 and its binding partner class III phosphoinositide 3-kinase (PI3K), also named Vps34, are required for the initiation of the formation of the autophagosome in autophagy. This gene participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. Schizophrenia is associated with low levels of Beclin-1 in the hippocampus of the affected which causes diminished autophagywhich in turn results in increased neuronal cell death. It has been found that beclin-1 can promote autophagy in autophagy-defective yeast with a targeted disruption of apg6/vps30, and in human MCF7 breast carcinoma cells.
NCBI and Uniprot Product Information
NCBI Description
Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009 [PubMed 19270693]).[supplied by OMIM, Jul 2010]
Uniprot Description
beclin 1: an essential autophagy protein that has been linked to multiple processes including tumor suppression, protection against some cardiac and neurological degenerative diseases, and lifespan extension. A ubiquitous protein of the beclin family. Is part of the class III PI3K complex that induces autophagy. Expressed at elevated levels in dendrites and cell bodies of cerebellar Purkinje cells. Interacts with the anti-apoptotic protein Bcl-2, which inhibits autophagy when it is present in the endoplasmic reticulum. The dissociation of ATG6 from Bcl-2 is essential for its autophagic activity. Interacts with PITC and GluR-delta2. Probably forms a complex with AMBRA1 and PIK3C3. Plays a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.
Protein type: Autophagy; Membrane protein, peripheral; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: extrinsic to membrane; mitochondrion; endoplasmic reticulum; cytoplasmic membrane-bound vesicle; dendrite; trans-Golgi network; phagocytic vesicle; nucleus; endosome
Molecular Function: protein binding; phosphoinositide 3-kinase binding
Biological Process: response to drug; viral reproduction; late endosome to vacuole transport; cytokinesis; CVT pathway; cellular response to nitrogen starvation; negative regulation of cell proliferation; response to vitamin E; regulation of catalytic activity; lysosome organization and biogenesis; beta-amyloid metabolic process; mitochondrion degradation; response to hypoxia; neuron development; cellular defense response; positive regulation of macroautophagy; defense response to virus; positive regulation of autophagy; negative regulation of apoptosis; autophagic vacuole formation
Research Articles on BECN1
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Product Notes
The BECN1 becn1 (Catalog #AAA177035) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Beclin 1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Beclin 1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Researchers should empirically determine the suitability of the BECN1 becn1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Beclin 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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