Rabbit BCL2L3 Polyclonal Antibody | anti-BCL2L3 antibody
BCL2L3 antibody
Applications
Western Blot
Purity
BCL2L3 antibody was purified by affinity chromatography
Synonyms
BCL2L3; Polyclonal Antibody; BCL2L3 antibody; Polyclonal BCL2L3; Anti-BCL2L3; Myeloid cell leukemia sequence 1; MCL1; BCLL3-2; BCLL3 2; anti-BCL2L3 antibody
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
BCL2L3 antibody was purified by affinity chromatography
Form/Format
Supplied in lyophilized form
Applicable Applications for anti-BCL2L3 antibody
Western Blot (WB)
Application Notes
Optimal conditions to be determined by the end user
Biological Significance
BCL2L3 encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing.Using the methods of somatic cell hybrid analysis and fluorescence in situ hybridization), the MCL1 gene is mapped to human 1q21.MCL1is a critical and specific regulator essential for ensuring the homeostasis of early hematopoietic progenitors.Phosphorylation of MCL1 directs its interaction with the tumor suppressor protein FBW7, which is the substrate-binding component of a ubiquitin ligase complex. The polyubiquitylation of MCL1 then targets it for proteasomal degradation. The degradation of MCL1 was blocked in patient-derived tumor cells that lacked FBW7 or had loss-of-function mutations in FBW7, conferring resistance to antitubulin agents and promoting chemotherapeutic-induced polyploidy.
Immunogen
BCL2L3 antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence at the C-terminal of human BCL2L3, different from the related Rabbit sequence by one amino acid, as the immunogen
Preparation and Storage
Store at 4 degree C for short term storage. For long term storage aliquot and store at -20 degree C, avoid repeated freeze/thaw cycles.
Related Product Information for anti-BCL2L3 antibody
Affinity purified Rabbit polyclonal BCL2L3 antibody
Product Categories/Family for anti-BCL2L3 antibody
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Product Notes
The BCL2L3 (Catalog #AAA5300388) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's BCL2L3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Optimal conditions to be determined by the end user. Researchers should empirically determine the suitability of the BCL2L3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BCL2L3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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