Rabbit BCL2A1 Polyclonal Antibody | anti-BCL2A1 antibody

Rabbit Polyclonal to Human BCL2A1

Cat. Num. AAA241252

• Gene Names: BCL2A1; GRS; BFL1; ACC-1; ACC-2; HBPA1; BCL2L5
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: BCL2A1; Polyclonal Antibody; Rabbit Polyclonal to Human BCL2A1; Anti-BCL2A1 Antibody (N-Terminus) IHC-plus; ACC-1; ACC-2; Bcl-2-like protein 5; Bcl-2-related protein A1; BCL2-related protein A1; BFL1; Bcl2-L-5; BCL2L5; GRS; HBPA1; Protein BFL-1; Protein GRS; Human BCL2A1; anti-BCL2A1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: 14 amino acid peptide from near the amino terminus of human Bfl-1
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.02% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 175

• Applicable Applications for anti-BCL2A1 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
• Application Notes: IHC-P (10 ug/ml), WB (1 - 2 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
• Target Species: Human
• Immunogen Description: A 14 amino acid peptide from near the amino terminus of human Bfl-1.
• Immunogen Type: Synthetic peptide
• Immunogen: BCL2A1 antibody was raised against a 14 amino acid peptide from near the amino terminus of human Bfl-1.
• Antigen Modification: N-Terminus
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Immunohistochemistry (IHC)

(Anti-BCL2A1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

Immunofluorescence (IF)

(Immunofluorescence of Bfl-1 in Mouse Kidney cells with Bfl-1 antibody at 20 ug/ml.)

Western Blot (WB)

(Western blot of Bfl-1 in mouse kidney tissue lysate with Bfl-1 antibody at (A) 1 and (B) 2 ug/ml.)

Related Product Information for anti-BCL2A1 antibody

This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation.

Product Categories/Family for anti-BCL2A1 antibody

Family: Apoptosis

NCBI and Uniprot Product Information

• NCBI GI #: 4757840
• NCBI GeneID: 597
• NCBI Accession #: NP_004040.1
• NCBI GenBank Nucleotide #: NM_004049.3
• UniProt Accession #: Q16548; Q6FGZ4; Q6FH19; Q86W13; Q99524
• Molecular Weight: 18,746 Da
• NCBI Official Full Name: bcl-2-related protein A1 isoform 1
• NCBI Official Synonym Full Names: BCL2-related protein A1
• NCBI Official Symbol: BCL2A1
• NCBI Official Synonym Symbols: GRS; BFL1; ACC-1; ACC-2; HBPA1; BCL2L5
• NCBI Protein Information: bcl-2-related protein A1; bcl2-L-5; protein BFL-1; bcl-2-like protein 5; hematopoietic BCL2-related protein A1; hemopoietic-specific early response protein
• UniProt Protein Name: Bcl-2-related protein A1
• Protein Family: Bcl-2-related protein
• UniProt Gene Name: BCL2A1
• UniProt Synonym Gene Names: BCL2L5; BFL1; GRS; HBPA1; Bcl2-L-5
• UniProt Entry Name: B2LA1_HUMAN

NCBI Description

This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

BCL2A1: Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection. Interacts directly with BAK1, BID, BMF and BBC3. Interacts directly with BCL2L11/BIM. Interacts with BAX isoform Sigma. Interacts directly with PMAIP1. By phorbol ester and inflammatory cytokines, such as TNF or IL1B/interleukin-1 beta, but not by growth factors. Seems to be restricted to the hematopoietic compartment. Expressed in peripheral blood, spleen, and bone marrow, at moderate levels in lung, small intestine and testis, at a minimal levels in other tissues. Also found in vascular smooth muscle cells and hematopoietic malignancies. Belongs to the Bcl-2 family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 15q24.3

Cellular Component: mitochondrial outer membrane

Molecular Function: BH domain binding; protein binding; protein homodimerization activity; protein heterodimerization activity

Biological Process: DNA damage response, signal transduction resulting in induction of apoptosis; negative regulation of apoptosis