Testing Data
(Peptide Competition: Lysates prepared from SK-BR3 cells left untreated (1) or treated with vinblastine (2-5) were incubated with MBS626983 following prior incubation with: no peptide (1, 2), the non-phosphopeptide corresponding to the immunogen (3), a generic phosphoserine-containing peptide (4), or, the phosphopeptide immunogen (5). The data show that only the peptide corresponding to Bcl-xL [pS62] blocks the signal, verifying the specificity of the antibody.)
Rabbit anti-Human Bcl-XL Polyclonal Antibody | anti-BCL2L1 antibody
Bcl-XL, phosphorylated (Ser62)
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Dilution: Western Blot: 1:1000
Testing Data
(Peptide Competition: Lysates prepared from SK-BR3 cells left untreated (1) or treated with vinblastine (2-5) were incubated with MBS626983 following prior incubation with: no peptide (1, 2), the non-phosphopeptide corresponding to the immunogen (3), a generic phosphoserine-containing peptide (4), or, the phosphopeptide immunogen (5). The data show that only the peptide corresponding to Bcl-xL [pS62] blocks the signal, verifying the specificity of the antibody.)
Testing Data
(Peptide Competition: Lysates prepared from SK-BR3 cells left untreated (1) or treated with vinblastine (2-5) were incubated with MBS626983 following prior incubation with: no peptide (1, 2), the non-phosphopeptide corresponding to the immunogen (3), a generic phosphoserine-containing peptide (4), or, the phosphopeptide immunogen (5). The data show that only the peptide corresponding to Bcl-xL [pS62] blocks the signal, verifying the specificity of the antibody.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq, Jul 2008]
Uniprot Description
Bcl-xL: an antiapoptotic member of the Bcl-2 family. Located at the outer mitochondrial membrane and regulates outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are potent inducers of cell apoptosis. Two alternatively spliced isoforms have been reported.
Protein type: Membrane protein, integral; Apoptosis; Autophagy; Mitochondrial
Chromosomal Location of Human Ortholog: 20q11.21
Cellular Component: centrosome; mitochondrial outer membrane; nuclear membrane; mitochondrion; synaptic vesicle membrane; mitochondrial matrix; cytoplasm; mitochondrial inner membrane; integral to membrane; nucleolus; cytosol; cell junction; nucleus
Molecular Function: identical protein binding; protein binding; protein homodimerization activity; protein heterodimerization activity; BH3 domain binding; protein kinase binding
Biological Process: negative regulation of autophagy; release of cytochrome c from mitochondria; in utero embryonic development; apoptosis; mitotic cell cycle checkpoint; suppression by virus of host apoptosis; male gonad development; cytokinesis; endocytosis; cellular process regulating host cell cycle in response to virus; germ cell development; cell proliferation; neuron apoptosis; apoptotic mitochondrial changes; fertilization; DNA damage response, signal transduction resulting in induction of apoptosis; ovarian follicle development; regulation of mitochondrial membrane potential; response to cytokine stimulus; positive regulation of cell proliferation; innate immune response; response to cycloheximide; spermatogenesis; regulation of mitochondrial membrane permeability; negative regulation of neuron apoptosis; growth; negative regulation of apoptosis
Research Articles on BCL2L1
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Product Notes
The BCL2L1 bcl2l1 (Catalog #AAA626983) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Bcl-XL, phosphorylated (Ser62) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Bcl-XL can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in ELISA and Western Blot. Dilution: Western Blot: 1:1000. Researchers should empirically determine the suitability of the BCL2L1 bcl2l1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Bcl-XL, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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